Ozlem Mermut1, Berrin Inanc. 1. University of Health Sciences, Istanbul Training and Research Hospital, Clinic of Radiation Oncology, Istanbul, Turkey.
Abstract
AIM: To evaluate the prognostic value of preoperative neutrophil-to-lymphocyte ratio and platelet-lymphocyte ratio in glioblastoma multiforme patients. MATERIAL AND METHODS: A total of 75 patients retrospectively analysed. The complete blood count of the patients was analysed before surgery. In our study, cut-off values for PLR 150 (platelet-lymphocyte ratio) and NLR 4 (neutrophil-to-lymphocyte ratio) were found to be significant by creating the ROC curve. Overall survival (OS) was calculated from surgery to death or the last contact. Progression-free survival (PFS) was calculated from surgery to progression. The last follow-up was November 2018. RESULTS: The median OS was significantly shorter in PLR > 150 patients (p=0.005; 10 vs 17 months). And the median OS was significantly shorter in NLR > 4 patients too (p=0.010; 11 vs 17 months). In multivariate analysis, Karnofsky performance score < 70 (HR:2.96, 95% CI:1.68-5.21; p < 0.001), type of surgical resection (HR:2.32, 95% CI:1.35-3.98; p=0.002) were statistically significant for PFS. In multivariate analysis, KPS < 70 (HR:2.72, 95% CI:1.30-5.67; p < 0.007), type of surgical resection (HR:2.09, 95% CI:1.10- 3.95; p=0.023), NLR > 4 (HR:2.14, 95% CI:1.11-4.14; p=0.023) were statistically significant for OS were found to be independent prognostic factor. CONCLUSION: The presence of 70 < KPS and type of surgical resection in patients with GBM had a negative effect on PFS. NLR > 4, 70 < KPS, type of surgical resection were independent prognostic factors that negatively affect for the OS.
AIM: To evaluate the prognostic value of preoperative neutrophil-to-lymphocyte ratio and platelet-lymphocyte ratio in glioblastoma multiformepatients. MATERIAL AND METHODS: A total of 75 patients retrospectively analysed. The complete blood count of the patients was analysed before surgery. In our study, cut-off values for PLR 150 (platelet-lymphocyte ratio) and NLR 4 (neutrophil-to-lymphocyte ratio) were found to be significant by creating the ROC curve. Overall survival (OS) was calculated from surgery to death or the last contact. Progression-free survival (PFS) was calculated from surgery to progression. The last follow-up was November 2018. RESULTS: The median OS was significantly shorter in PLR > 150 patients (p=0.005; 10 vs 17 months). And the median OS was significantly shorter in NLR > 4 patients too (p=0.010; 11 vs 17 months). In multivariate analysis, Karnofsky performance score < 70 (HR:2.96, 95% CI:1.68-5.21; p < 0.001), type of surgical resection (HR:2.32, 95% CI:1.35-3.98; p=0.002) were statistically significant for PFS. In multivariate analysis, KPS < 70 (HR:2.72, 95% CI:1.30-5.67; p < 0.007), type of surgical resection (HR:2.09, 95% CI:1.10- 3.95; p=0.023), NLR > 4 (HR:2.14, 95% CI:1.11-4.14; p=0.023) were statistically significant for OS were found to be independent prognostic factor. CONCLUSION: The presence of 70 < KPS and type of surgical resection in patients with GBM had a negative effect on PFS. NLR > 4, 70 < KPS, type of surgical resection were independent prognostic factors that negatively affect for the OS.