Javier Santabárbara1,2,3, Darren M Lipnicki4, Beatriz Olaya3,5, Beatriz Villagrasa6, Juan Bueno-Notivol7, Lucia Nuez1, Raúl López-Antón2,3,8, Patricia Gracia-García7. 1. Department of Preventive Medicine and Public Health, Universidad de Zaragoza, 50009 Zaragoza, Spain. 2. Instituto de Investigación Sanitaria de Aragón (IIS Aragón), 50009 Zaragoza, Spain. 3. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, 28029 Madrid, Spain. 4. Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, Randwick, Sydney, NSW 2052, Australia. 5. Research, Innovation and Teaching Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, 08830 Sant Boi de Llobregat, Spain. 6. Psychogeriatry, CASM Benito Menni, 08830 Sant Boi de Llobregat, Spain. 7. Psychiatry Service, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain. 8. Department of Psychology and Sociology, Universidad de Zaragoza, 50009 Zaragoza, Spain.
Abstract
Background: Anxiety has been suggested as a potentially modifiable risk factor for dementia, but results are still controversial. Our main objectives are to develop an updated meta-analysis of prospective population-based studies on the relationship between anxiety and risk of dementia, and to estimate the population fraction of dementia attributable to anxiety (PAF). Methods: We searched for cohort studies listed on PubMed or Web of Science from January 2018 to January 2020 that reported risk estimates for the association between anxiety and incident dementia. These were added to cohort studies published before January 2018 that were used in a previously published meta-analysis. Fully adjusted RRs were pooled using random effects models. We estimated the proportion of incident dementia attributable to anxiety by using PAF. Results: The meta-analysis included nine prospective cohorts from eight studies, representing 29,608 participants. The overall relative risk (RR) of dementia was 1.24 (95% CI: 1.06-1.46) and the PAF of dementia due to anxiety was 3.9%. Conclusions: Anxiety is significantly associated with an increased risk of all-cause dementia. The treatment or prevention of anxiety might help to reduce dementia incidence rates, but more research is needed to clarify whether anxiety is a cause of dementia rather than a prodrome.
Background: Anxiety has been suggested as a potentially modifiable risk factor for dementia, but results are still controversial. Our main objectives are to develop an updated meta-analysis of prospective population-based studies on the relationship between anxiety and risk of dementia, and to estimate the population fraction of dementia attributable to anxiety (PAF). Methods: We searched for cohort studies listed on PubMed or Web of Science from January 2018 to January 2020 that reported risk estimates for the association between anxiety and incident dementia. These were added to cohort studies published before January 2018 that were used in a previously published meta-analysis. Fully adjusted RRs were pooled using random effects models. We estimated the proportion of incident dementia attributable to anxiety by using PAF. Results: The meta-analysis included nine prospective cohorts from eight studies, representing 29,608 participants. The overall relative risk (RR) of dementia was 1.24 (95% CI: 1.06-1.46) and the PAF of dementia due to anxiety was 3.9%. Conclusions: Anxiety is significantly associated with an increased risk of all-cause dementia. The treatment or prevention of anxiety might help to reduce dementia incidence rates, but more research is needed to clarify whether anxiety is a cause of dementia rather than a prodrome.
Authors: Yun Freudenberg-Hua; Alexander Makhnevich; Wentian Li; Yan Liu; Michael Qiu; Allison Marziliano; Maria Carney; Blaine Greenwald; John M Kane; Michael Diefenbach; Edith Burns; Jeremy Koppel; Liron Sinvani Journal: Front Med (Lausanne) Date: 2022-03-18
Authors: Jessie O T Kwok; Rachel W K Yan; Charlotte P C Kwok; Gabriel W H Cheng; Cuichan Lin; Brian H C Wong; Sheung Tak Cheng; Allen T C Lee; Linda C W Lam Journal: Front Psychiatry Date: 2022-09-14 Impact factor: 5.435