Huseyin Kocaturk1, Fevzi Bedir1, Mehmet Sefa Altay1, Ebubekir Bakan2, Bahadir Suleyman3, Gulce Naz Yazici4, Mukadder Sunar5, Zeynep Suleyman6, Halis Suleyman3. 1. Department of Urology, Health Sciences University, Erzurum Regional Training and Research Hospital, Erzurum, Turkey. 2. Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey. 3. Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. 4. Department of Histology and Embryology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. 5. Department of Anatomy, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. 6. Department of Nursing, Faculty of Health Sciences, Erzincan Binali Yildirim University, Erzincan, Turkey.
Abstract
Purpose: To examine the effect of desloratadine on kidney ischemia-reperfusion (I/R) injury in albino Wistar male rats using biochemical and histopathological methods. Methods: The treated with ischemia-reperfusion + 5 mg/kg desloratadine (IRD) group (n-6) was given 5 mg/kg desloratadine by gavage orally, and applied renal ischemia-reperfusion (BIR) group (n-6) and control (SG) group undergoing Sham operation (n-6) rats were given distilled water as solvent one hour before ketamine anesthesia. During the anesthesia period, ischemia was induced for 2 h unilaterally in the left kidney of all rats followed by reperfusion for 6 h. The kidneys of the SG group had sham operation without any intervention. Results: Our biochemical test results showed that malondialdehyde (MDA), nuclear factor kappa (NF-κB), tumor necrosis factor alpha (TNF-α), interleukin one beta (IL-1β), creatinine, and blood urea nitrogen (BUN) levels were significantly increased in the BIR group compared to the healthy control and IRD groups treated with desloratadine. Histopathological results were revealed tubular dilatation, tubular necrosis, loss of brushy margins, cast formation, and apoptotic bodies in tubular epithelial cells in the BIR group. There were no histopathological findings except for the swelling of tubule epithelial cells and the accumulation of proteinous material in some tubule lumens in renal tissue of desloratadine-treated rats.Conclusions: Experimental results suggested that desloratadine may be useful in the treatment of renal I/R injury.
Purpose: To examine the effect of desloratadine on kidney ischemia-reperfusion (I/R) injury in albino Wistar male rats using biochemical and histopathological methods. Methods: The treated with ischemia-reperfusion + 5 mg/kg desloratadine (IRD) group (n-6) was given 5 mg/kg desloratadine by gavage orally, and applied renal ischemia-reperfusion (BIR) group (n-6) and control (SG) group undergoing Sham operation (n-6) rats were given distilled water as solvent one hour before ketamine anesthesia. During the anesthesia period, ischemia was induced for 2 h unilaterally in the left kidney of all rats followed by reperfusion for 6 h. The kidneys of the SG group had sham operation without any intervention. Results: Our biochemical test results showed that malondialdehyde (MDA), nuclear factor kappa (NF-κB), tumor necrosis factor alpha (TNF-α), interleukin one beta (IL-1β), creatinine, and blood ureanitrogen (BUN) levels were significantly increased in the BIR group compared to the healthy control and IRD groups treated with desloratadine. Histopathological results were revealed tubular dilatation, tubular necrosis, loss of brushy margins, cast formation, and apoptotic bodies in tubular epithelial cells in the BIR group. There were no histopathological findings except for the swelling of tubule epithelial cells and the accumulation of proteinous material in some tubule lumens in renal tissue of desloratadine-treated rats.Conclusions: Experimental results suggested that desloratadine may be useful in the treatment of renal I/R injury.
Authors: C Roumestan; C Henriquet; C Gougat; A Michel; F Bichon; K Portet; D Jaffuel; M Mathieu Journal: Clin Exp Allergy Date: 2008-06 Impact factor: 5.018
Authors: Ömer Topdağı; Ayhan Tanyeli; Fazile Nur Ekinci Akdemir; Ersen Eraslan; Mustafa Can Güler; Selim Çomaklı Journal: Life Sci Date: 2019-12-26 Impact factor: 5.037
Authors: Asmaa Mohammed ShamsEldeen; Sarah A Abd El-Aal; Basma Emad Aboulhoda; Hend AbdAllah; Sara Mahmoud Gamal; Fatma E Hassan; Marwa Nagi Mehesen; Laila Ahmed Rashed; Abeer Mostafa; Nermeen Bakr Sadek Journal: Front Physiol Date: 2022-06-23 Impact factor: 4.755