Eric A Pasman1,2, Bruce Ong1,3, Claire P Witmer1,2, Cade M Nylund4,5. 1. Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, USA. 2. Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 3. Department of Allergy and Immunology, Walter Reed National Military Medical Center, Bethesda, MD, USA. 4. Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, USA. cade.nylund@usuhs.edu. 5. Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. cade.nylund@usuhs.edu.
Abstract
PURPOSE OF REVIEW: The evidence supporting or contesting the prescription of proton pump inhibitors (PPIs) for children and updates on side effects are reviewed. RECENT FINDINGS: PPIs remain an important therapeutic option for esophagitis and gastritis. However, recent studies demonstrate no benefit when prescribing PPIs for chronic cough, infantile reflux, asthma, or functional gastrointestinal disorders. Recent studies suggest adverse effects on microbiome diversity and immune function, resulting in increased rates of gastrointestinal infections, bone fractures, and atopic disorders. PPIs influence a variety of cell types within the in the innate and adaptive immune systems. PPI prescriptions in children may be indicated for select conditions; however, multiple side effects and immune effects have been described. While most of these side effects are rare and mild, some studies suggest enduring adverse effects. Future studies to elucidate the mechanism behind some of these immune and infectious complications will be beneficial.
PURPOSE OF REVIEW: The evidence supporting or contesting the prescription of proton pump inhibitors (PPIs) for children and updates on side effects are reviewed. RECENT FINDINGS: PPIs remain an important therapeutic option for esophagitis and gastritis. However, recent studies demonstrate no benefit when prescribing PPIs for chronic cough, infantile reflux, asthma, or functional gastrointestinal disorders. Recent studies suggest adverse effects on microbiome diversity and immune function, resulting in increased rates of gastrointestinal infections, bone fractures, and atopic disorders. PPIs influence a variety of cell types within the in the innate and adaptive immune systems. PPI prescriptions in children may be indicated for select conditions; however, multiple side effects and immune effects have been described. While most of these side effects are rare and mild, some studies suggest enduring adverse effects. Future studies to elucidate the mechanism behind some of these immune and infectious complications will be beneficial.
Entities:
Keywords:
Allergy; Children; Immunology; Proton pump inhibitor; Side effects