| Literature DB >> 32524098 |
Kittika Poonsombudlert1, Jakrin Kewcharoen1, Chattip Prueksapraopong2, Nath Limpruttidham1.
Abstract
Engraftment syndrome (ES) has been associated with the surge of neutrophils and cytokines, which is similar to the presumed underlying pathophysiology behind acute graft-versus-host disease (aGVHD). However, there has been no meta-analysis to evaluate the association; therefore, the team attempted to verify an association between ES and aGVHD through meta-analysis. The team searched for titles of articles in MEDLINE (PubMed), the Cochrane Library, and the EMBASE database up until December 2018 that evaluated the association between ES and aGVHD and conducted a random effect meta-analysis of 8 studies involving a total of 1,945 participants to report the pooled odds ratio (OR) for association of ES and aGVHD. The team found a significantly increased odds of developing aGVHD in patients with ES with the pooled OR of 2.76 (95% confidence interval [CI]: 1.64-4.63) and an I2 = 64.5%. In conclusion, patients with ES have significantly higher odds of developing aGVHD compared to patients without ES. ©Copyright 2020 by University Health Partners of Hawai‘i (UHP Hawai‘i).Entities:
Keywords: acute graft-versus-host disease; auto-aggression syndrome; capillary leakage syndrome; engraftment syndrome; meta-analysis
Mesh：
Year: 2020 PMID： 32524098 PMCID： PMC7281341
Source DB: PubMed Journal: Hawaii J Health Soc Welf ISSN： 2641-5216