A system for administering quantified doses of tobacco smoke to human subjects: plasma nicotine and filter pad validation.

A new, automated system for administering quantified doses of cigarette smoke to human subjects is described and results of two studies demonstrating the reliability and validity of the system are presented. To overcome the large variability in nicotine and tar delivery associated with previous means of controlling smoke delivery, an automated quantified smoke delivery system was constructed. The system increases the precision and reliability of the smoke and nicotine dose delivered to human subjects. The quantified smoke delivery system was found to deliver doses of nicotine with a substantially greater degree of precision than procedures typically used in previous laboratory studies of smoking behavior.