Marco Invernizzi1, Alessandro de Sire2,3, Stefano Carda4, Konstantinos Venetis5,6, Filippo Renò7, Carlo Cisari2,8, Nicola Fusco6,9. 1. Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy. marco.invernizzi@med.uniupo.it. 2. Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy. 3. Rehabilitation Unit, "Mons. L. Novarese" Hospital, Moncrivello, Vercelli, Italy. 4. Neuropsychology and Neurorehabilitation Service, Department of Clinical Neuroscience, Lausanne University Hospital (CHUV), Lausanne, Switzerland. 5. Ph.D. Program in Translational Medicine, University of Milan, Milan, Italy. 6. Division of Pathology, IRCCS European Institute of Oncology (IEO), Milan, Italy. 7. Innovative Research Laboratory for Wound Healing, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy. 8. Physical Medicine and Rehabilitation Unit, University Hospital "Maggiore della Carità", Novara, Italy. 9. Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Abstract
PURPOSE OF REVIEW: The goal of this review is to provide a comprehensive overview of (i) bone and muscle tissue modifications pathophysiology in spinal cord injury (SCI), (ii) experimental data on the physiopathological mechanisms underpinning these modifications and their similarities with the aging process, and (iii) potential clinical implications in the management of the disabling sequelae of SCI. RECENT FINDINGS: Several studies attempted to describe the biology underpinning the links between bone and muscle tissues in the setting of highly disabling conditions, such as osteoporosis, sarcopenia, and neurodegenerative disorders, although these bidirectional connections remain still unclear. SCI could be considered an in vivo paradigmatic model of the bone muscle interactions in unloading conditions that might be expanded in the field of neurodegenerative disorders or cancer studies. Future studies should take into consideration the newer insights into bone muscle crosstalk in order to develop multitargeted and therapeutic interventions.
PURPOSE OF REVIEW: The goal of this review is to provide a comprehensive overview of (i) bone and muscle tissue modifications pathophysiology in spinal cord injury (SCI), (ii) experimental data on the physiopathological mechanisms underpinning these modifications and their similarities with the aging process, and (iii) potential clinical implications in the management of the disabling sequelae of SCI. RECENT FINDINGS: Several studies attempted to describe the biology underpinning the links between bone and muscle tissues in the setting of highly disabling conditions, such as osteoporosis, sarcopenia, and neurodegenerative disorders, although these bidirectional connections remain still unclear. SCI could be considered an in vivo paradigmatic model of the bone muscle interactions in unloading conditions that might be expanded in the field of neurodegenerative disorders or cancer studies. Future studies should take into consideration the newer insights into bone muscle crosstalk in order to develop multitargeted and therapeutic interventions.
Authors: Piera Lalli; Claudia Mautino; Chiara Busso; Francesca Bardesono; Marco Di Monaco; Lorenzo Lippi; Marco Invernizzi; Marco Alessandro Minetto Journal: J Clin Med Date: 2022-06-29 Impact factor: 4.964
Authors: Marco Invernizzi; Lorenzo Lippi; Arianna Folli; Alessio Turco; Lorenzo Zattoni; Antonio Maconi; Alessandro de Sire; Nicola Fusco Journal: Front Mol Biosci Date: 2022-09-08
Authors: Marco Invernizzi; Alessandro de Sire; Lorenzo Lippi; Konstantinos Venetis; Elham Sajjadi; Francesca Gimigliano; Alessandra Gennari; Carmen Criscitiello; Carlo Cisari; Nicola Fusco Journal: Front Oncol Date: 2020-10-21 Impact factor: 6.244