Literature DB >> 32519036

A potential cause of asbestos-related granulomatosis due to adulterant contamination in a drug abuser.

Maria Concetta Lazzaro1,2, Sabrina Romanò1,2,3, Sergio Santoro4, Cristian Camuto1,2, Arnaldo Carbone2,5, Rosario Casamassima3, Sergio Abate3, Fabio De-Giorgio6,7.   

Abstract

Drug adulterants containing contaminants have been known to cause lung disease by inhalation or intravenous intake. Talcosis due to intravenous talc injection has been widely described in the literature, whereas the hypothesis of granulomatosis due to asbestos related to adulterated cocaine injection has not yet been explored. Herein, a case of pulmonary granulomatosis due to asbestos fibres related to cocaine injection in a young woman is described. Inorganic material in the lung was first individuated by light microscopy and last was identified using the SEM-EDX method. This case is unique since the occupational and passive inhalation of asbestos was excluded with absolute certainty.

Entities:  

Keywords:  Adulterant contamination; Asbestos; Autopsy; Drug abuse; Intravenous cocaine; Lung granulomas; Pathological findings; Post-mortem investigation; Talc

Year:  2020        PMID: 32519036     DOI: 10.1007/s00428-020-02863-z

Source DB:  PubMed          Journal:  Virchows Arch        ISSN: 0945-6317            Impact factor:   4.064


  3 in total

Review 1.  Mechanisms in the pathogenesis of asbestosis and silicosis.

Authors:  B T Mossman; A Churg
Journal:  Am J Respir Crit Care Med       Date:  1998-05       Impact factor: 21.405

2.  Is histological examination always necessary to determine a cause of death? Of course it is!

Authors:  Fabio De-Giorgio; Giuseppe Vetrugno
Journal:  Forensic Sci Med Pathol       Date:  2014-03-01       Impact factor: 2.007

Review 3.  Asbestos-related cancers: the 'Hidden Killer' remains a global threat.

Authors:  Nico van Zandwijk; Glen Reid; Arthur L Frank
Journal:  Expert Rev Anticancer Ther       Date:  2020-03-29       Impact factor: 4.512

  3 in total

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