Literature DB >> 32518965

Description of an atypical Toxoplasma gondii isolate from a case of congenital toxoplasmosis in northeastern Brazil.

Renata Pimentel Bandeira de Melo1, Flaviana Santos Wanderley2, Wagnner José Nascimento Porto3, Camila de Morais Pedrosa4, Clare M Hamilton5, Maria Heloísa Gomes Silva de Oliveira4, Müller Ribeiro-Andrade6, Renata Camila da Silva Rêgo2, Frank Katzer5, Rinaldo A Mota6.   

Abstract

We report a case of severe congenital toxoplasmosis that involved an atypical T. gondii genotype in a newborn baby from Alagoas state in Northeastern Brazil. A pregnant woman presented IgM and IgG anti-T. gondii antibodies, as detected by the chemiluminescence immunoassay on the second trimester of pregnancy. A mouse bioassay was performed using umbilical cord blood and one isolate was obtained. The isolate was designated TgCTBrAL1 and genetic characterization revealed genotype ToxoDB #162. Genotype results of the rhoptry genes, ROP5 and ROP18, could predict the high virulence of the isolate in mice, which was confirmed by an in vivo virulence assay. This is the first report of generating a T. gondii isolate from a newborn baby with congenital toxoplasmosis in Northeastern Brazil.

Entities:  

Keywords:  Genotyping; Mouse bioassay; Newborn; Virulence

Mesh：

Substances：

Year:  2020        PMID： 32518965     DOI： 10.1007/s00436-020-06746-9

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  16 in total

1.  IMPROVED TECHNIQUE OF INDIRECT IMMUNOFLUORESCENCE FOR SEROLOGICAL DIAGNOSIS OF TOXOPLASMOSIS.

Authors:  M E CAMARGO
Journal:  Rev Inst Med Trop Sao Paulo       Date:  1964 May-Jun       Impact factor: 1.846

Review 2.  Severe congenital toxoplasmosis due to a Toxoplasma gondii strain with an atypical genotype: case report and review.

Authors:  Laurence Delhaes; Daniel Ajzenberg; Bérangère Sicot; Philippe Bourgeot; Marie-Laure Dardé; Eduardo Dei-Cas; Véronique Houfflin-Debarge
Journal:  Prenat Diagn       Date:  2010-09       Impact factor: 3.050

3.  Application of phylogenetic networks in evolutionary studies.

Authors:  Daniel H Huson; David Bryant
Journal:  Mol Biol Evol       Date:  2005-10-12       Impact factor: 16.240

4.  PCR-RFLP genotyping of Toxoplasma gondii from chickens from Espírito Santo state, Southeast region, Brazil: new genotypes and a new SAG3 marker allele.

Authors:  H F J Pena; S N Vitaliano; M A V Beltrame; F E L Pereira; S M Gennari; R M Soares
Journal:  Vet Parasitol       Date:  2012-10-11       Impact factor: 2.738

5.  Biological and genetic characterisation of Toxoplasma gondii isolates from chickens (Gallus domesticus) from São Paulo, Brazil: unexpected findings.

Authors:  J P Dubey; D H Graham; C R Blackston; T Lehmann; S M Gennari; A M A Ragozo; S M Nishi; S K Shen; O C H Kwok; D E Hill; P Thulliez
Journal:  Int J Parasitol       Date:  2002-01       Impact factor: 3.981

6.  Evidence of the three main clonal Toxoplasma gondii lineages from wild mammalian carnivores in the UK.

Authors:  A Burrells; P M Bartley; I A Zimmer; S Roy; A C Kitchener; A Meredith; S E Wright; E A Innes; F Katzer
Journal:  Parasitology       Date:  2013-08-19       Impact factor: 3.234

7.  First isolation and genotyping of Toxoplasma gondii from bats (Mammalia: Chiroptera).

Authors:  A D Cabral; A R Gama; M M Sodré; E S M M Savani; M A Galvão-Dias; L R Jordão; M M Maeda; L E O Yai; S M Gennari; H F J Pena
Journal:  Vet Parasitol       Date:  2012-11-12       Impact factor: 2.738

8.  Genetic characterization of Toxoplasma gondii revealed highly diverse genotypes for isolates from newborns with congenital toxoplasmosis in southeastern Brazil.

Authors:  Ana Carolina Aguiar Vasconcelos Carneiro; Gláucia Manzan Andrade; Júlia Gatti Ladeia Costa; Breno Veloso Pinheiro; Daniel Vitor Vasconcelos-Santos; Adriana Melo Ferreira; Chunlei Su; José Nélio Januário; Ricardo Wagner Almeida Vitor
Journal:  J Clin Microbiol       Date:  2013-01-02       Impact factor: 5.948

9.  Population structure and mouse-virulence of Toxoplasma gondii in Brazil.

Authors:  H F J Pena; S M Gennari; J P Dubey; C Su
Journal:  Int J Parasitol       Date:  2007-09-21       Impact factor: 3.981

Review 10.  Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review.

Authors:  Annie Elbez-Rubinstein; Daniel Ajzenberg; Marie-Laure Dardé; Robert Cohen; Aurélien Dumètre; Hélène Yera; Emmanuelle Gondon; Jean-Claude Janaud; Philippe Thulliez
Journal:  J Infect Dis       Date:  2009-01-15       Impact factor: 5.226
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