Literature DB >> 32515223

Oral intake of lipopolysaccharide regulates toll-like receptor 4-dependent granulopoiesis.

Melanie Märklin1,2, Stefanie Bugl3, Stefan Wirths3, Julia-Stefanie Frick4, Martin R Müller3,5, Hans-Georg Kopp3,6, Dominik Schneidawind2,3.   

Abstract

IMPACT STATEMENT: In our present study, we investigated the impact of LPS on neutrophil homeostasis and found that oral intake is sufficient to induce hematopoietic stem and progenitor cell fate decisions towards the neutrophil lineage independent of G-CSF. In addition, TLR4 has been identified as the indispensable sensor for oral LPS-modulated steady-state granulopoiesis. We provide evidence that the gastrointestinal microbiome is critical for neutrophil homeostasis, which has implications for patients being treated with chemotherapy or antimicrobial therapy, since both are significantly influencing the composition of the intestinal microbiome.

Entities:  

Keywords:  G-CSF; Lipopolysaccharide; TLR4; granulocytes; granulopoiesis

Mesh：

Substances：

Year:  2020        PMID： 32515223      PMCID： PMC7437373          DOI： 10.1177/1535370220931043

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  17 in total

1.  Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation.

Authors:  F Liu; J Poursine-Laurent; H Y Wu; D C Link
Journal:  Blood       Date:  1997-10-01       Impact factor: 22.113

2.  The influence of gut-decontamination prophylactic antibiotics on acute graft-versus-host disease and survival following allogeneic hematopoietic stem cell transplantation.

Authors:  Bertrand Routy; Caroline Letendre; David Enot; Maxime Chénard-Poirier; Vikram Mehraj; Noémie Charbonneau Séguin; Khaled Guenda; Kathia Gagnon; Paul-Louis Woerther; David Ghez; Silvy Lachance
Journal:  Oncoimmunology       Date:  2016-12-27       Impact factor: 8.110

3.  Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness.

Authors:  Hitoshi Takizawa; Kristin Fritsch; Larisa V Kovtonyuk; Yasuyuki Saito; Chakradhar Yakkala; Kurt Jacobs; Akshay K Ahuja; Massimo Lopes; Annika Hausmann; Wolf-Dietrich Hardt; Álvaro Gomariz; César Nombela-Arrieta; Markus G Manz
Journal:  Cell Stem Cell       Date:  2017-07-20       Impact factor: 24.633

4.  "Emergency" granulopoiesis in G-CSF-deficient mice in response to Candida albicans infection.

Authors:  S Basu; G Hodgson; H H Zhang; M Katz; C Quilici; A R Dunn
Journal:  Blood       Date:  2000-06-15       Impact factor: 22.113

5.  NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.

Authors:  Julia Skokowa; Dan Lan; Basant Kumar Thakur; Fei Wang; Kshama Gupta; Gunnar Cario; Annette Müller Brechlin; Axel Schambach; Lars Hinrichsen; Gustav Meyer; Matthias Gaestel; Martin Stanulla; Qiang Tong; Karl Welte
Journal:  Nat Med       Date:  2009-02-01       Impact factor: 53.440

Review 6.  Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research.

Authors:  Carol Kilkenny; William J Browne; Innes C Cuthill; Michael Emerson; Douglas G Altman
Journal:  PLoS Biol       Date:  2010-06-29       Impact factor: 8.029

7.  Probiotic Lactobacillus strains protect against myelosuppression and immunosuppression in cyclophosphamide-treated mice.

Authors:  Susana Salva; Gabriela Marranzino; Julio Villena; Graciela Agüero; Susana Alvarez
Journal:  Int Immunopharmacol       Date:  2014-06-24       Impact factor: 4.932

8.  An analogue of lipid A and LPS from Rhodobacter sphaeroides inhibits neutrophil responses to LPS by blocking receptor recognition of LPS and by depleting LPS-binding protein in plasma.

Authors:  Y Aida; K Kusumoto; K Nakatomi; H Takada; M J Pabst; K Maeda
Journal:  J Leukoc Biol       Date:  1995-12       Impact factor: 4.962

9.  Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli.

Authors:  Callie A Norris; Mu He; Liang-I Kang; Michael Qi Ding; Josiah E Radder; Meagan M Haynes; Yu Yang; Shirish Paranjpe; William C Bowen; Anne Orr; George K Michalopoulos; Donna B Stolz; Wendy M Mars
Journal:  PLoS One       Date:  2014-04-24       Impact factor: 3.240

10.  Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice.

Authors:  Tomas Hrncir; Renata Stepankova; Hana Kozakova; Tomas Hudcovic; Helena Tlaskalova-Hogenova
Journal:  BMC Immunol       Date:  2008-11-06       Impact factor: 3.615
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  1 in total

Review 1.  The Yin and Yang of Immunity in Stem Cell Decision Guidance in Tissue Ecologies: An Infection Independent Perspective.

Authors:  Vaishali Garg; Shashank Chandanala; M David-Luther; M Govind; Roshni Ravi Prasad; Anujith Kumar; S Jyothi Prasanna
Journal:  Front Cell Dev Biol       Date:  2022-02-07
  1 in total

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