Zhenxiu Gao1,2, Wei Yan1, Zhaohui Fang3, Zongjun Zhang1, Li Yuan4, Xiaoyun Wang5, Zhumin Jia6, Yuanyuan Zhu2, Joshua D Miller7, Xiaodan Yuan1, Fan Li8, Qingqing Lou1. 1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China. 2. Nursing College, Nanjing University of Chinese Medicine, Nanjing, China. 3. Department of Endocrinology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China. 4. West China Medical School, West China Hospital, Sichuan University, Chengdu, China. 5. Department of Endocrinology, Shan'xi Provincial People's Hospital, Taiyuan, China. 6. The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China. 7. Stony Brook University Hospital, New York City, New York, USA. 8. College of Nursing, University of Missouri St. Louis, St. Louis, Missouri, USA.
Abstract
BACKGROUND: The aim of this study was to investigate the annual decline of β-cell function correlated with disease duration in patients with type 2 diabetes in China. METHODS: This cross-sectional study included 4792 adults with type 2 diabetes who were recruited from four university hospital diabetes clinics between April 2018 and November 2018. Baseline data were collected from electric medical records. Participants were divided into 21 groups with 1-year diabetes duration interval to assess the decline rate of β-cell function. Homeostatic model assessment model (HOMA 2) model was applied to assess β-cell function. Multiple linear regression model was used to evaluate the association between biochemical and clinical variables and β-cell function. RESULTS: In Chinese patients with type 2 diabetes, β-cell function declined by 2% annually. Using angiotensin receptor blockade (ARB) (β = .048; P = .011), metformin (β = .138; P = .021), or insulin (β = .142; P = .018) was associated with increased β-cell function. However, increased BMI (β = -.215; P = .022), alcohol consumption (β = -.331; P < .001), haemoglobin A1c (β = -.104; P = .027), or increased diabetes duration (β = -.183; P = .003) was significantly and negatively associated with β-cell function. CONCLUSIONS: We determined that the annual rate of the β-cell function decline was 2% in patients with type 2 diabetes in China. Moreover, we confirmed a positive relationship between ARB treatment and β-cell function, while BMI and alcohol consumption were significantly and negatively associated with the β-cell function.
BACKGROUND: The aim of this study was to investigate the annual decline of β-cell function correlated with disease duration in patients with type 2 diabetes in China. METHODS: This cross-sectional study included 4792 adults with type 2 diabetes who were recruited from four university hospital diabetes clinics between April 2018 and November 2018. Baseline data were collected from electric medical records. Participants were divided into 21 groups with 1-year diabetes duration interval to assess the decline rate of β-cell function. Homeostatic model assessment model (HOMA 2) model was applied to assess β-cell function. Multiple linear regression model was used to evaluate the association between biochemical and clinical variables and β-cell function. RESULTS: In Chinese patients with type 2 diabetes, β-cell function declined by 2% annually. Using angiotensin receptor blockade (ARB) (β = .048; P = .011), metformin (β = .138; P = .021), or insulin (β = .142; P = .018) was associated with increased β-cell function. However, increased BMI (β = -.215; P = .022), alcohol consumption (β = -.331; P < .001), haemoglobin A1c (β = -.104; P = .027), or increased diabetes duration (β = -.183; P = .003) was significantly and negatively associated with β-cell function. CONCLUSIONS: We determined that the annual rate of the β-cell function decline was 2% in patients with type 2 diabetes in China. Moreover, we confirmed a positive relationship between ARB treatment and β-cell function, while BMI and alcohol consumption were significantly and negatively associated with the β-cell function.
Authors: Calvin Ke; Thérèse A Stukel; Baiju R Shah; Eric Lau; Ronald C Ma; Wing-Yee So; Alice P Kong; Elaine Chow; Juliana C N Chan; Andrea Luk Journal: PLoS Med Date: 2020-09-18 Impact factor: 11.069