Weiwei Ruan1,2, Xun Sun1,2, Xuehan Hu1,2, Fang Liu1,2, Fan Hu1,2, Jinxia Guo3, Yongxue Zhang1,2, Xiaoli Lan4,5. 1. Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, China. 2. Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China. 3. GE Healthcare, Shanghai, 201203, China. 4. Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, China. xiaoli_lan@hust.edu.cn. 5. Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, China. xiaoli_lan@hust.edu.cn.
Abstract
BACKGROUND: Quantitative analysis of brain positron-emission tomography (PET) depends on structural segmentation, which can be time-consuming and operator-dependent when performed manually. Previous automatic segmentation usually registered subjects' images onto an atlas template (defined as RSIAT here) for group analysis, which changed the individuals' images and probably affected regional PET segmentation. In contrast, we could register atlas template to subjects' images (RATSI), which created an individual atlas template and may be more accurate for PET segmentation. We segmented two representative brain areas in twenty Parkinson disease (PD) and eight multiple system atrophy (MSA) patients performed in hybrid positron-emission tomography/magnetic resonance imaging (PET/MR). The segmentation accuracy was evaluated using the Dice coefficient (DC) and Hausdorff distance (HD), and the standardized uptake value (SUV) measurements of these two automatic segmentation methods were compared, using manual segmentation as a reference. RESULTS: The DC of RATSI increased, and the HD decreased significantly (P < 0.05) compared with the RSIAT in PD, while the results of one-way analysis of variance (ANOVA) found no significant differences in the SUVmean and SUVmax among the two automatic and the manual segmentation methods. Further, RATSI was used to compare regional differences in cerebral metabolism pattern between PD and MSA patients. The SUVmean in the segmented cerebellar gray matter for the MSA group was significantly lower compared with the PD group (P < 0.05), which is consistent with previous reports. CONCLUSION: The RATSI was more accurate for the caudate nucleus and putamen automatic segmentation and can be used for regional PET analysis in hybrid PET/MR.
BACKGROUND: Quantitative analysis of brain positron-emission tomography (PET) depends on structural segmentation, which can be time-consuming and operator-dependent when performed manually. Previous automatic segmentation usually registered subjects' images onto an atlas template (defined as RSIAT here) for group analysis, which changed the individuals' images and probably affected regional PET segmentation. In contrast, we could register atlas template to subjects' images (RATSI), which created an individual atlas template and may be more accurate for PET segmentation. We segmented two representative brain areas in twenty Parkinson disease (PD) and eight multiple system atrophy (MSA) patients performed in hybrid positron-emission tomography/magnetic resonance imaging (PET/MR). The segmentation accuracy was evaluated using the Dice coefficient (DC) and Hausdorff distance (HD), and the standardized uptake value (SUV) measurements of these two automatic segmentation methods were compared, using manual segmentation as a reference. RESULTS: The DC of RATSI increased, and the HD decreased significantly (P < 0.05) compared with the RSIAT in PD, while the results of one-way analysis of variance (ANOVA) found no significant differences in the SUVmean and SUVmax among the two automatic and the manual segmentation methods. Further, RATSI was used to compare regional differences in cerebral metabolism pattern between PD and MSA patients. The SUVmean in the segmented cerebellar gray matter for the MSA group was significantly lower compared with the PD group (P < 0.05), which is consistent with previous reports. CONCLUSION: The RATSI was more accurate for the caudate nucleus and putamen automatic segmentation and can be used for regional PET analysis in hybrid PET/MR.
Entities:
Keywords:
Atlas-based; Multiple system atrophy; PET/MR; Parkinson disease; Segmentation
Authors: Artur Agaronyan; Raeyan Syed; Ryan Kim; Chao-Hsiung Hsu; Scott A Love; Jacob M Hooker; Alicia E Reid; Paul C Wang; Nobuyuki Ishibashi; Yeona Kang; Tsang-Wei Tu Journal: Front Neuroanat Date: 2022-01-14 Impact factor: 3.856