Shurong Dong1,2,3, Ya Yang1,2,3, Yingjian Wang1,2,3, Dongjian Yang1,2,3, Yu Yang1,2,3, Ying Shi1,2,3, Chunlin Li1,2,3, Linhan Li1,2,3, Yue Chen4, Qingwu Jiang1,2,3, Yibiao Zhou5,6,7. 1. Fudan University School of Public Health, Xuhui District, Building 8, 130 Dong An Road, Shanghai, 200032, China. 2. Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Building 8, 130 Dong An Road, Xuhui District, Shanghai, 200032, China. 3. Fudan University Center for Tropical Disease Research, Building 8, 130 Dong An Road, Xuhui District, Shanghai, 200032, China. 4. School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1H 8M5, Canada. 5. Fudan University School of Public Health, Xuhui District, Building 8, 130 Dong An Road, Shanghai, 200032, China. z_yibiao@hotmail.com. 6. Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Building 8, 130 Dong An Road, Xuhui District, Shanghai, 200032, China. z_yibiao@hotmail.com. 7. Fudan University Center for Tropical Disease Research, Building 8, 130 Dong An Road, Xuhui District, Shanghai, 200032, China. z_yibiao@hotmail.com.
Abstract
BACKGROUND: Cryptosporidium is a protozoan parasite that can infect both humans and animals and cause cryptosporidiosis. We aimed to estimate the global prevalence of Cryptosporidium infection. METHODS: In this study, Web of Science, Medline and PubMed were searched for relative articles, published between January 1, 1960 and January 1, 2018. Included articles were restricted to English language and that sample size of articles was not less than 50. Studies with no information on the study period, location, method of diagnosis, sample size and number of infected people were excluded. Studies about outbreak, laboratory report or immunocompromised population were excluded as well. The quality of the included publications was assessed. The prevalence of cryptosporidiosis was estimated by DerSimonian-Laird random-effects model, after converting by the Freeman-Tukey type double arcsine transformation. FINDINGS: From 13,064 publications selected by literature search, 221 studies were included in the meta-analysis. The global pooled prevalence of Cryptosporidium infection was 7.6 % (95% CI: 6.9-8.5). The highest estimated prevalence of Cryptosporidium infection was in Mexico (69.6%, 95% CI 66.3-72.8), Nigeria (34.0%, 95% CI 12.4-60.0), Bangladesh (42.5%, 95% CI 36.1-49.0) and Republic of Korea (8.3%, 95% CI 4.4-13.2) among general residents, patients, school children and healthy population, respectively. The estimated prevalence was high in people from low-income country, people with gastrointestinal symptoms, people younger than 5 years old and residents not living in urban areas. CONCLUSIONS: These estimates indicate the substantial prevalence of Cryptosporidium infection in the world, which may provide a theoretical basis for the formulation of the prevention strategy about Cryptosporidium.
BACKGROUND: Cryptosporidium is a protozoan parasite that can infect both humans and animals and cause cryptosporidiosis. We aimed to estimate the global prevalence of Cryptosporidium infection. METHODS: In this study, Web of Science, Medline and PubMed were searched for relative articles, published between January 1, 1960 and January 1, 2018. Included articles were restricted to English language and that sample size of articles was not less than 50. Studies with no information on the study period, location, method of diagnosis, sample size and number of infectedpeople were excluded. Studies about outbreak, laboratory report or immunocompromised population were excluded as well. The quality of the included publications was assessed. The prevalence of cryptosporidiosis was estimated by DerSimonian-Laird random-effects model, after converting by the Freeman-Tukey type double arcsine transformation. FINDINGS: From 13,064 publications selected by literature search, 221 studies were included in the meta-analysis. The global pooled prevalence of Cryptosporidium infection was 7.6 % (95% CI: 6.9-8.5). The highest estimated prevalence of Cryptosporidium infection was in Mexico (69.6%, 95% CI 66.3-72.8), Nigeria (34.0%, 95% CI 12.4-60.0), Bangladesh (42.5%, 95% CI 36.1-49.0) and Republic of Korea (8.3%, 95% CI 4.4-13.2) among general residents, patients, school children and healthy population, respectively. The estimated prevalence was high in people from low-income country, people with gastrointestinal symptoms, people younger than 5 years old and residents not living in urban areas. CONCLUSIONS: These estimates indicate the substantial prevalence of Cryptosporidium infection in the world, which may provide a theoretical basis for the formulation of the prevention strategy about Cryptosporidium.
Entities:
Keywords:
Cryptosporidiosis; Cryptosporidium; Global health; Meta-analysis; Prevalence; Protozoan infections
Authors: Marwa Esmat; Amany A Abdel-Aal; Maisa A Shalaby; Manal Badawi; Hala Elaskary; Ahmed Badawi Yousif; Mennat-Elrahman A Fahmy Journal: Food Waterborne Parasitol Date: 2022-05-04
Authors: Vipin K Menon; Pablo C Okhuysen; Cynthia L Chappell; Medhat Mahmoud; Medhat Mahmoud; Qingchang Meng; Harsha Doddapaneni; Vanesa Vee; Yi Han; Sejal Salvi; Sravya Bhamidipati; Kavya Kottapalli; George Weissenberger; Hua Shen; Matthew C Ross; Kristi L Hoffman; Sara Javornik Cregeen; Donna M Muzny; Ginger A Metcalf; Richard A Gibbs; Joseph F Petrosino; Fritz J Sedlazeck Journal: Gigascience Date: 2022-02-15 Impact factor: 6.524
Authors: Mamun Kabir; Masud Alam; Uma Nayak; Tuhinur Arju; Biplob Hossain; Rubaiya Tarannum; Amena Khatun; Jennifer A White; Jennie Z Ma; Rashidul Haque; William A Petri; Carol A Gilchrist Journal: PLoS Pathog Date: 2021-06-28 Impact factor: 6.823