Filippo Vaccari1,2, Angelina Passaro3,4, Andrea D'Amuri3, Juana Maria Sanz3, Francesca Di Vece4, Eleonora Capatti4, Benedetta Magnesa5, Marina Comelli5, Irene Mavelli5, Bruno Grassi5, Federica Fiori5, Giulia Bravo5, Alice Avancini6, Maria Parpinel5, Stefano Lazzer5,7. 1. Department of Medicine, University of Udine, P.le Kolbe 4, 33100, Udine, Italy. vaccari.filippo@spes.uniud.it. 2. School of Sport Sciences, University of Udine, Udine, Italy. vaccari.filippo@spes.uniud.it. 3. Department of Medical Science, University of Ferrara, Ferrara, Italy. 4. Department of Medicine, Azienda Ospedaliera Universitaria di Ferrara, Ferrara, Italy. 5. Department of Medicine, University of Udine, P.le Kolbe 4, 33100, Udine, Italy. 6. Biomedical, Clinical and Experimental Sciences, Department of Medicine, University of Verona, Verona, Italy. 7. School of Sport Sciences, University of Udine, Udine, Italy.
Abstract
PURPOSE: The purpose of this study was to investigate, in obese adults, changes in body composition, physical capacities, fat oxidation and ex vivo mitochondrial respiration induced by a 3-month either moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT); afterwards, the patients were followed for four months. METHODS:Thirty-two patients (mean age 39 years; mean body mass index [BMI] 36 kg∙m-2) participated in this study attending ~ 34 sessions of training. At baseline (PRE), at the end of the program (POST) and after follow-up, body composition, peak O2 uptake (V'O2peak) and fat oxidation rate were measured. Vastus lateralis biopsies for the evaluation of mitochondrial respiration were performed only at PRE and POST. RESULTS: At POST, body mass (BM) and fat mass (FM) decreased (- 6 and - 14%, respectively, P < 0.05) in MICT and HIIT; V'O2peak increased in both groups (+ 6 and + 16%, respectively, P < 0.05). Maximal fat oxidation rate increased only after HIIT (P < 0.001). Maximal ADP-stimulated mitochondrial respiration normalized by citrate synthase increased (P < 0.05) by 67% and 36% in MICT and HIIT, respectively, without significant difference. After follow-up, BM and FM were still lower (- 4 and - 20%, respectively, P < 0.050) compared with baseline in both groups. Only after HIIT, V'O2peak (+ 8%) and maximal fat oxidation rate were still higher (P < 0.05). CONCLUSIONS: HIIT was more effective in improving and maintaining V'O2peak and fat oxidation. These results may be relevant for an appropriate prescription of training programs designed to optimize aerobic fitness in obese subjects.
RCT Entities:
PURPOSE: The purpose of this study was to investigate, in obese adults, changes in body composition, physical capacities, fat oxidation and ex vivo mitochondrial respiration induced by a 3-month either moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT); afterwards, the patients were followed for four months. METHODS: Thirty-two patients (mean age 39 years; mean body mass index [BMI] 36 kg∙m-2) participated in this study attending ~ 34 sessions of training. At baseline (PRE), at the end of the program (POST) and after follow-up, body composition, peak O2 uptake (V'O2peak) and fat oxidation rate were measured. Vastus lateralis biopsies for the evaluation of mitochondrial respiration were performed only at PRE and POST. RESULTS: At POST, body mass (BM) and fat mass (FM) decreased (- 6 and - 14%, respectively, P < 0.05) in MICT and HIIT; V'O2peak increased in both groups (+ 6 and + 16%, respectively, P < 0.05). Maximal fat oxidation rate increased only after HIIT (P < 0.001). Maximal ADP-stimulated mitochondrial respiration normalized by citrate synthase increased (P < 0.05) by 67% and 36% in MICT and HIIT, respectively, without significant difference. After follow-up, BM and FM were still lower (- 4 and - 20%, respectively, P < 0.050) compared with baseline in both groups. Only after HIIT, V'O2peak (+ 8%) and maximal fat oxidation rate were still higher (P < 0.05). CONCLUSIONS: HIIT was more effective in improving and maintaining V'O2peak and fat oxidation. These results may be relevant for an appropriate prescription of training programs designed to optimize aerobic fitness in obese subjects.
Authors: Jaime Gallo-Villegas; Leonardo A Castro-Valencia; Laura Pérez; Daniel Restrepo; Oscar Guerrero; Sergio Cardona; Yeliana L Sánchez; Manuela Yepes-Calderón; Luis H Valbuena; Miguel Peña; Andrés F Milán; Maria C Trillos-Almanza; Sergio Granados; Juan C Aristizabal; Mauricio Estrada-Castrillón; Raúl Narvaez-Sanchez; Jorge Osorio; Daniel C Aguirre-Acevedo; Juan C Calderón Journal: Eur J Appl Physiol Date: 2021-10-23 Impact factor: 3.078
Authors: Isaac A Chávez-Guevara; Rosa P Hernández-Torres; Everardo González-Rodríguez; Arnulfo Ramos-Jiménez; Francisco J Amaro-Gahete Journal: Eur J Appl Physiol Date: 2022-04-01 Impact factor: 3.346