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Literature DB >> 32513795

Antimicrobial Susceptibility and Clonality of Vaginally Derived Multidrug-Resistant Mobiluncus Isolates in China.

Xueying Zhang¹, Yongying Bai¹, Long Zhang¹, Mohamed S Draz^2,3, Zhi Ruan⁴, Yuning Zhu^5,6.

Abstract

Here, the antimicrobial susceptibility, resistance mechanisms, and clonality of Mobiluncus sp. isolates recovered from gynecological outpatients in China were investigated. Compared to M. mulieris, M. curtisii exhibited higher antimicrobial resistance to metronidazole, clindamycin, and tetracycline. Whole-genome sequencing indicated that the clindamycin resistance gene erm(X) was located on a transposable element, Tn5432, which was composed of two IS1249 sequences. Phylogenetic analysis indicated that Mobiluncus spp. had high diversity, with isolates being grouped into several sporadic clades.

Entities: Chemical Species

Keywords: Mobiluncus spp.; antimicrobial resistance; clindamycin; metronidazole; whole-genome sequencing

Mesh：

Substances：

Year: 2020 PMID： 32513795 PMCID： PMC7526835 DOI： 10.1128/AAC.00780-20

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

31 in total

1. Sexually transmitted diseases treatment guidelines, 2015.

Authors: Kimberly A Workowski; Gail A Bolan
Journal: MMWR Recomm Rep Date: 2015-06-05

2. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract.

Authors: Melis N Anahtar; Elizabeth H Byrne; Kathleen E Doherty; Brittany A Bowman; Hidemi S Yamamoto; Magali Soumillon; Nikita Padavattan; Nasreen Ismail; Amber Moodley; Mary E Sabatini; Musie S Ghebremichael; Chad Nusbaum; Curtis Huttenhower; Herbert W Virgin; Thumbi Ndung'u; Krista L Dong; Bruce D Walker; Raina N Fichorova; Douglas S Kwon
Journal: Immunity Date: 2015-05-19 Impact factor: 31.745

3. Susceptibility of bacterial vaginosis (BV)-associated bacteria to secnidazole compared to metronidazole, tinidazole and clindamycin.

Authors: Melinda A B Petrina; Lisa A Cosentino; Lorna K Rabe; Sharon L Hillier
Journal: Anaerobe Date: 2017-05-15 Impact factor: 3.331

4. Mobiluncus species in gynaecological and obstetric infections: antimicrobial resistance and prevalence in a Turkish population.

Authors: Hrisi Bahar; Müzeyyen Mamal Torun; Fahri Oçer; Bekir Kocazeybek
Journal: Int J Antimicrob Agents Date: 2005-03 Impact factor: 5.283

5. Structure determination of CAMP factor of Mobiluncus curtisii and insights into structural dynamics.

Authors: Weihong Zeng; Huan Ma; Weirong Fan; Yunru Yang; Caiying Zhang; John Arnaud Kombe Kombe; Xiaojiao Fan; Yuzhu Zhang; Zhongjun Dong; Zhen Shen; Ying Zhou; Meixiang Yang; Tengchuan Jin
Journal: Int J Biol Macromol Date: 2019-11-15 Impact factor: 6.953

1. Genomic Insights Into the Interspecific Diversity and Evolution of Mobiluncus, a Pathogen Associated With Bacterial Vaginosis.

Authors: Yisong Li; Ying Wang; Jie Liu
Journal: Front Microbiol Date: 2022-07-05 Impact factor: 6.064

1 in total

Antimicrobial Susceptibility and Clonality of Vaginally Derived Multidrug-Resistant Mobiluncus Isolates in China.

1. Sexually transmitted diseases treatment guidelines, 2015.

2. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract.

3. Susceptibility of bacterial vaginosis (BV)-associated bacteria to secnidazole compared to metronidazole, tinidazole and clindamycin.

4. Mobiluncus species in gynaecological and obstetric infections: antimicrobial resistance and prevalence in a Turkish population.

5. Structure determination of CAMP factor of Mobiluncus curtisii and insights into structural dynamics.

6. Antimicrobial susceptibility of anaerobic bacteria in Belgium as determined by E-test methodology.

7. Antibiotic susceptibility profiles of anaerobic pathogens in The Netherlands.

8. BacWGSTdb, a database for genotyping and source tracking bacterial pathogens.

9. nim gene-independent metronidazole-resistant Bacteroides fragilis in surgical site infections.

10. Characterization of a stable, metronidazole-resistant Clostridium difficile clinical isolate.

1. Genomic Insights Into the Interspecific Diversity and Evolution of Mobiluncus, a Pathogen Associated With Bacterial Vaginosis.