Alberto M Borobia1, Antonio J Carcas1, Francisco Arnalich2, Rodolfo Álvarez-Sala3, Jaime Monserrat-Villatoro1, Manuel Quintana4, Juan Carlos Figueira4, Rosario M Torres Santos-Olmo5, Julio García-Rodríguez6, Alberto Martín-Vega7, Antonio Buño8, Elena Ramírez1, Gonzalo Martínez-Alés9, Nicolás García-Arenzana10, M Concepción Núñez11, Milagros Martí-de-Gracia12, Francisco Moreno Ramos13, Francisco Reinoso-Barbero14, Alejandro Martin-Quiros5, Angélica Rivera Núñez5, Jesús Mingorance6, Carlos J Carpio Segura3, Daniel Prieto Arribas8, Esther Rey Cuevas15, Concepción Prados Sánchez3, Juan J Rios2, Miguel A Hernán16, Jesús Frías1, José R Arribas2. 1. Clinical Pharmacology Department, La Paz University Hospital-IdiPAZ, Universidad Autónoma de Madrid, 28046 Madrid, Spain. 2. Internal Medicine Department, La Paz University Hospital-IdiPAZ, Universidad Autónoma de Madrid, 28046 Madrid, Spain. 3. Pneumology Department, La Paz University Hospital-IdiPAZ, Universidad Autónoma de Madrid, 28046 Madrid, Spain. 4. Intensive Care Unit, La Paz University Hospital-IdiPAZ, Universidad Autónoma de Madrid, 28046 Madrid, Spain. 5. Emergency Department, La Paz University Hospital-IdiPAZ, Universidad Autónoma de Madrid, 28046 Madrid, Spain. 6. Microbiology Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain. 7. CSUR Coordination, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain. 8. Laboratory Medicine Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain. 9. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA. 10. Preventive Medicine Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain. 11. Risk Prevention Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain. 12. Emergency Radiology Unit, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain. 13. Pharmacy Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain. 14. Anesthesiology Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain. 15. Nursing Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain. 16. Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Harvard-MIT Division of Health Sciences and Technology, Boston, MA 02115, USA.
Abstract
BACKGROUND: Since the confirmation of the first patient infected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. METHODS: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. RESULTS: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients' median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. CONCLUSIONS: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.
BACKGROUND: Since the confirmation of the first patientinfected with SARS-CoV-2 in Spain in January 2020, the epidemic has grown rapidly, with the greatest impact on the region of Madrid. This article describes the first 2226 adult patients with COVID-19, consecutively admitted to La Paz University Hospital in Madrid. METHODS: Our cohort included all patients consecutively hospitalized who had a final outcome (death or discharge) in a 1286-bed hospital of Madrid (Spain) from 25 February (first case admitted) to 19 April 2020. The data were manually entered into an electronic case report form, which was monitored prior to the analysis. RESULTS: We consecutively included 2226 adult patients admitted to the hospital who either died (460) or were discharged (1766). The patients' median age was 61 years, and 51.8% were women. The most common comorbidity was arterial hypertension (41.3%), and the most common symptom on admission was fever (71.2%). The median time from disease onset to hospital admission was 6 days. The overall mortality was 20.7% and was higher in men (26.6% vs. 15.1%). Seventy-five patients with a final outcome were transferred to the intensive care unit (ICU) (3.4%). Most patients admitted to the ICU were men, and the median age was 64 years. Baseline laboratory values on admission were consistent with an impaired immune-inflammatory profile. CONCLUSIONS: We provide a description of the first large cohort of hospitalized patients with COVID-19 in Europe. Advanced age, male sex, the presence of comorbidities and abnormal laboratory values were more common among the patients with fatal outcomes.
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Authors: Felix M Reyes; Manuel Hache-Marliere; Dimitris Karamanis; Cesar G Berto; Rodolfo Estrada; Matthew Langston; George Ntaios; Perminder Gulani; Chirag D Shah; Leonidas Palaiodimos Journal: J Clin Med Date: 2021-05-13 Impact factor: 4.241