Literature DB >> 32511763

Colchicine and COVID-19.

Pablo Corral1, Gonzalo Corral2, Rafael Diaz3.   

Abstract

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Year:  2020        PMID: 32511763      PMCID: PMC7300998          DOI: 10.1002/jcph.1684

Source DB:  PubMed          Journal:  J Clin Pharmacol        ISSN: 0091-2700            Impact factor:   2.860


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We read with interest the Letter to the Editor titled “Can Colchicine as an Old Anti‐Inflammatory Agent Be Effective in COVID‐19?” by Nasiripour et al., in which the authors stated that only 1 phase 3 multicenter, randomized, double‐blind, placebo‐controlled multicenter study has been assigned to clinicaltrials.gov by the Montreal Heart Institute to investigate the efficacy and safety of colchicine in adult patients diagnosed with COVID‐19. In Argentina, we started COLCOVID Trial to test the effects of colchicine on moderate‐/high‐risk hospitalized COVID‐19 patients with the aim of reducing mortality. This study is a phase 3 multicenter, controlled trial; our protocol was published in ClinicalTrial.gov on March 31, 2020. Therefore, we would like to affirm that, besides the COLCORONA Trial, there is another study ongoing focused on colchicine in COVID‐19. We appreciate the opportunity to express our comment following the recent publication of the potential role of colchicine in SARS‐CoV‐2 infection.

Conflicts of Interest

Pablo Corral reports honoraria for lectures from Amgen, Sanofi, AstraZeneca, and PTC; research grants from Amgen and Genzyme, and personal fees for consultancy from Amgen, Novartis, and Sanofi. Rafael Diaz reports research grants from Sanofi, DalCor, Population Health Research Institute, Duke Clinical Research Institute, the TIMI group, Amgen, Cirius, Montreal Health Innovations Coordinating Center, and Lepetit and personal fees from Amgen and Cirius.
  1 in total

1.  Can Colchicine as an Old Anti-Inflammatory Agent Be Effective in COVID-19?

Authors:  Somayyeh Nasiripour; Farhad Zamani; Maryam Farasatinasab
Journal:  J Clin Pharmacol       Date:  2020-05-23       Impact factor: 3.126

  1 in total
  4 in total

1.  The Novel Coronavirus and Inflammation.

Authors:  J A George; E S Mayne
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 2.  Efficacy of Colchicine in the Treatment of COVID-19 Patients: A Systematic Review and Meta-Analysis.

Authors:  Carlos J Toro-Huamanchumo; Jerry K Benites-Meza; Carlos S Mamani-García; Diego Bustamante-Paytan; Abraham Edgar Gracia-Ramos; Cristian Diaz-Vélez; Joshuan J Barboza
Journal:  J Clin Med       Date:  2022-05-06       Impact factor: 4.964

3.  Colchicine Blocks Tubulin Heterodimer Recycling by Tubulin Cofactors TBCA, TBCB, and TBCE.

Authors:  Sofia Nolasco; Javier Bellido; Marina Serna; Bruno Carmona; Helena Soares; Juan Carlos Zabala
Journal:  Front Cell Dev Biol       Date:  2021-04-22

4.  The Challenge of Managing Children With Periodic Fever Syndromes in the Era of COVID-19.

Authors:  Rita Consolini; Giorgio Costagliola; Marco Gattorno
Journal:  Front Pediatr       Date:  2021-01-06       Impact factor: 3.418

  4 in total

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