Literature DB >> 32509379

The role of mitochondrial dynamics in human cancers.

Yawen Ma1,2, Lihua Wang1,2, Renbing Jia1,2.   

Abstract

Mitochondria are crucial cellular organelles. Under extracellular stimulations, mitochondria undergo constant fusion and fission dynamics to meet different cellular demands. Mitochondrial dynamics is regulated by specialized proteins and lipids. Dysregulated mitochondrial dynamics has been linked to the initiation and progression of diverse human cancers, affecting aspects such as cancer metastasis, drug resistance and cancer stem cell survival, suggesting that targeting mitochondrial dynamics is a potential therapeutic strategy. In the present review, we summarize the molecular mechanisms underlying fusion and fission dynamics and discuss the effects of mitochondrial dynamics on the development of human cancers. AJCR
Copyright © 2020.

Entities:  

Keywords:  Mitochondrial dynamics; cancer stem cells; human cancers; lipids

Year:  2020        PMID： 32509379

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  17 in total

1.  Redecorating the Mitochondrial Inner Membrane: A Treatment for mtDNA Disorders.

Authors:  Zofia M A Chrzanowska-Lightowlers; Robert N Lightowlers
Journal:  Mol Ther       Date:  2020-07-16       Impact factor: 11.454

Review 2.  Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria.

Authors:  Prashanth Gowda; P Hemachandra Reddy; Subodh Kumar
Journal:  Ageing Res Rev       Date:  2021-11-20       Impact factor: 10.895

Review 3.  Mitochondrial dynamics regulators: implications for therapeutic intervention in cancer.

Authors:  Sanjay Kumar; Rahail Ashraf; Aparna C K
Journal:  Cell Biol Toxicol       Date:  2021-10-18       Impact factor: 6.691

Review 4.  Mitochondrial Dynamin-Related Protein Drp1: a New Player in Cardio-oncology.

Authors:  Yali Deng; Doan T M Ngo; Jessica K Holien; Jarmon G Lees; Shiang Y Lim
Journal:  Curr Oncol Rep       Date:  2022-10-01       Impact factor: 5.945

5.  Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer.

Authors:  Abhinav Achreja; Tao Yu; Anjali Mittal; Srinadh Choppara; Olamide Animasahun; Minal Nenwani; Fulei Wuchu; Noah Meurs; Aradhana Mohan; Jin Heon Jeon; Itisam Sarangi; Anusha Jayaraman; Sarah Owen; Reva Kulkarni; Michele Cusato; Frank Weinberg; Hye Kyong Kweon; Chitra Subramanian; Max S Wicha; Sofia D Merajver; Sunitha Nagrath; Kathleen R Cho; Analisa DiFeo; Xiongbin Lu; Deepak Nagrath
Journal:  Nat Metab       Date:  2022-09-21

Review 6.  Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis.

Authors:  Mary Adebayo; Seema Singh; Ajay Pratap Singh; Santanu Dasgupta
Journal:  FASEB J       Date:  2021-06       Impact factor: 5.834

Review 7.  Revisiting Mitochondria Scored Cancer Progression and Metastasis.

Authors:  Rohit Gundamaraju; Wenying Lu; Rishya Manikam
Journal:  Cancers (Basel)       Date:  2021-01-23       Impact factor: 6.639

8.  Rapamycin Ameliorates Defects in Mitochondrial Fission and Mitophagy in Glioblastoma Cells.

Authors:  Paola Lenzi; Rosangela Ferese; Francesca Biagioni; Federica Fulceri; Carla L Busceti; Alessandra Falleni; Stefano Gambardella; Alessandro Frati; Francesco Fornai
Journal:  Int J Mol Sci       Date:  2021-05-20       Impact factor: 5.923

Review 9.  Mitochondrial Dynamics and Liver Cancer.

Authors:  María Isabel Hernández-Alvarez; Antonio Zorzano
Journal:  Cancers (Basel)       Date:  2021-05-24       Impact factor: 6.639

10.  DDR1 Affects Metabolic Reprogramming in Breast Cancer Cells by Cross-Talking to the Insulin/IGF System.

Authors:  Veronica Vella; Marika Giuliano; Maria Luisa Nicolosi; Maria Giovanna Majorana; Małgorzata Anna Marć; Maria Grazia Muoio; Andrea Morrione; Marcello Maggiolini; Rosamaria Lappano; Ernestina Marianna De Francesco; Antonino Belfiore
Journal:  Biomolecules       Date:  2021-06-22
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