Carolina-Hartung Habibe1, Rosemeire-Arai Yoshida2, Renata Gorjão3, Gabriela-Mancia de Gutierrez4, Debora Heller5, Alexander Birbrair6, Maria-Teresa-Botti-Rodrigues Santos7. 1. DDS, MSc, PhD, Professor, Pediatric Dentistry, Centro Universitário de Volta Redonda, UniFOA, Av. Lucas Evangelista de Oliveira Franco, 866, Volta Redonda. Brazil. 2. DDS, MSc student, Postgraduate Program in Dentistry, Cruzeiro do Sul University, Rua Galvão Bueno, 868 - Liberdade, São Paulo. Brazil. 3. MSc, PhD, Adjunt Professor, Postgraduate Program Interdisciplinary in Health Sciences, Cruzeiro do Sul University, Rua Galvão Bueno, 868 - Liberdade, São Paulo. Brazil. 4. DDS, MSc, Ph.D student, Postgraduate Program in Dentistry, Cruzeiro do Sul University, Rua Galvão Bueno, 868 - Liberdade, São Paulo. Brazil. 5. DDS, MSc, PhD, School of Dentistry, Cruzeiro do Sul University, Rua Galvão Bueno, 868 - Liberdade, São Paulo - SP, 01506-000, Brazil. Experimental Research Center, Albert Einstein Israeli Hospital, São Paulo, São Paulo, Brazil. 6. DDS, MSc, PhD, Department of Radiology, Columbia University Medical Center, New York, New York 622 W 168th St, New York, NY 10032, EUA. Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. 7. DDS, MSc, PhD, Associate Professor, Individuals with Special Needs, Postgraduate Program in Dentistry, Cruzeiro do Sul University São Paulo, SP, Brazil.
Abstract
BACKGROUND: Individuals with Down syndrome (DS) present increased susceptibility to infections and high prevalence of periodontal disease. The objective of this study is to evaluate the salivary concentrations of IL-1β, IL-6, IL-8, IL-10, TNFα and IL-12p70 of DS individuals and compare to cerebral palsy (CP) and normoactive patients (all with gingivitis). MATERIAL AND METHODS: Twenty-two individuals with DS, 24 with CP and 22 normoactive participated in this cross-sectional study. Salivary flow rate, osmolality rate, Oral Hygiene Index, Gingival Index (GI) and salivary inflammatory markers IL-1β, IL-6, IL-8, IL-10, TNFα and IL-12p70 were evaluated. Shapiro-Wilks, Chi-square, ANOVA One-Way and Kruskal Wallis tests were applied with significance level at 5%. RESULTS: The groups were homogenous for gender, age, and IL12p70 cytokine (p>0.05). GI was significantly higher in DS compared to CP and healthy (p<0.05). CP presented reduced salivary flow and increased osmolality rate. CP showed significantly higher values for TNFα, IL10, and IL6 compared to DS and normoactive (p<0.05). DS and CP presented significantly higher values of IL-1β and IL8 compared to normoactive (p<0.05). CONCLUSIONS: Individuals with CP have higher risk to develop periodontal disease due to reduced salivary flow rate, increased salivary osmolality rate and elevated TNFα, IL-10, IL-6 compared to DS. Key words:Cytokines, biomarkers, gingivitis, periodontal diseases, Down syndrome, cerebral palsy, saliva. Copyright:
BACKGROUND: Individuals with Down syndrome (DS) present increased susceptibility to infections and high prevalence of periodontal disease. The objective of this study is to evaluate the salivary concentrations of IL-1β, IL-6, IL-8, IL-10, TNFα and IL-12p70 of DS individuals and compare to cerebral palsy (CP) and normoactive patients (all with gingivitis). MATERIAL AND METHODS: Twenty-two individuals with DS, 24 with CP and 22 normoactive participated in this cross-sectional study. Salivary flow rate, osmolality rate, Oral Hygiene Index, Gingival Index (GI) and salivary inflammatory markers IL-1β, IL-6, IL-8, IL-10, TNFα and IL-12p70 were evaluated. Shapiro-Wilks, Chi-square, ANOVA One-Way and Kruskal Wallis tests were applied with significance level at 5%. RESULTS: The groups were homogenous for gender, age, and IL12p70 cytokine (p>0.05). GI was significantly higher in DS compared to CP and healthy (p<0.05). CP presented reduced salivary flow and increased osmolality rate. CP showed significantly higher values for TNFα, IL10, and IL6 compared to DS and normoactive (p<0.05). DS and CP presented significantly higher values of IL-1β and IL8 compared to normoactive (p<0.05). CONCLUSIONS: Individuals with CP have higher risk to develop periodontal disease due to reduced salivary flow rate, increased salivary osmolality rate and elevated TNFα, IL-10, IL-6 compared to DS. Key words:Cytokines, biomarkers, gingivitis, periodontal diseases, Down syndrome, cerebral palsy, saliva. Copyright:
Authors: Mariana F Leite; Lauren Cardoso Alves Aznar; Maria Cristina D Ferreira; Renata O Guaré; Maria Teresa B Santos Journal: J Oral Pathol Med Date: 2013-02-12 Impact factor: 4.253
Authors: Søren Jepsen; Jack G Caton; Jasim M Albandar; Nabil F Bissada; Philippe Bouchard; Pierpaolo Cortellini; Korkud Demirel; Massimo de Sanctis; Carlo Ercoli; Jingyuan Fan; Nicolaas C Geurs; Francis J Hughes; Lijian Jin; Alpdogan Kantarci; Evanthia Lalla; Phoebus N Madianos; Debora Matthews; Michael K McGuire; Michael P Mills; Philip M Preshaw; Mark A Reynolds; Anton Sculean; Cristiano Susin; Nicola X West; Kazuhisa Yamazaki Journal: J Clin Periodontol Date: 2018-06 Impact factor: 8.728