CircRNAs: potency of protein translation and feasibility of novel biomarkers and therapeutic targets for head and neck cancers.

Circular RNAs (circRNAs), a new star noncoding RNA (ncRNA), show stability, conservation, abundance, and tissue and stage specificity. They act as key regulators of biological processes. They target the mRNAs of many other different genes or signaling pathways, and closely link associated genes into regulatory networks. Growing evidence has demonstrated that circRNAs may play an important role in the carcinogenesis, progression and chemoradiation resistance of many cancers including head and neck cancers (HNC). CircRNA, like other ncRNA, such as miRNA, lncRNA, usually is considered to be non-protein coding transcript. However, recent studies indicated that abnormal translation of circRNAs may be involved in human diseases. In this review, we collected the origin, classification, characteristics, function of circRNAs, exosmal circRNAs, and then synthesize current study results to highlight aberration of circRNAs in various types of HNC, and try to clarify the molecular mechanisms of circRNAs affecting the pathogenesis and progression of HNC, as well as pay particular attention to provide a new avenue to the diagnosis and treatment strategy for HNC. AJTR