Literature DB >> 32508365

Antiepileptic Drugs and Bone Health: Current Concepts.

Antonio Siniscalchi1, Sean Murphy1, Erika Cione1, Leonardo Piro1, Giovambattista De Sarro1, Luca Gallelli1.   

Abstract

Chronic use of antiepileptic drugs (AEDs) can induce the development of adverse effects on bone metabolism. In epileptic patients treated with AED, the monitoring of biochemical markers of bone turnover, such as the measurement of serum 25 (OH) vitamin D, bone mineral density, before the beginning of the treatment and during the follow-up is not routinely required. In the future, monitoring of biochemical markers in epileptic patients treated with AED may help us for adequate prevention therapy.
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Entities:  

Keywords:  antiepileptic drugs; biochemical markers; bone metabolism; vitamin D metabolism

Mesh：

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Year:  2020        PMID： 32508365      PMCID： PMC7255839     

Source DB:  PubMed          Journal:  Psychopharmacol Bull        ISSN： 0048-5764


  57 in total

Review 1.  Bone and calcium metabolism and antiepileptic drugs.

Authors:  Alberto Verrotti; Giangennaro Coppola; Pasquale Parisi; Angelika Mohn; Francesco Chiarelli
Journal:  Clin Neurol Neurosurg       Date:  2009-11-12       Impact factor: 1.876

Review 2.  Effects of antiepileptic drugs on bone mineral density and bone metabolism in children: a meta-analysis.

Authors:  Ying Zhang; Yu-xin Zheng; Jun-ming Zhu; Jian-min Zhang; Zhe Zheng
Journal:  J Zhejiang Univ Sci B       Date:  2015-07       Impact factor: 3.066

Review 3.  Bone loss associated with use of antiepileptic drugs.

Authors:  Karl O Nakken; Erik Taubøll
Journal:  Expert Opin Drug Saf       Date:  2010-07       Impact factor: 4.250

4.  Association of antiepileptic drugs with nontraumatic fractures: a population-based analysis.

Authors:  Nathalie Jetté; Lisa M Lix; Colleen J Metge; Heather J Prior; Jane McChesney; William D Leslie
Journal:  Arch Neurol       Date:  2011-01

5.  Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy.

Authors:  C Y Guo; G M Ronen; S A Atkinson
Journal:  Epilepsia       Date:  2001-09       Impact factor: 5.864

6.  Bone mineral density and vitamin D status in children with epilepsy, cerebral palsy, and cerebral palsy with epilepsy.

Authors:  Ayse Tosun; Seda Erisen Karaca; Tolga Unuvar; Yakup Yurekli; Cigdem Yenisey; Imran Kurt Omurlu
Journal:  Childs Nerv Syst       Date:  2016-10-18       Impact factor: 1.475

7.  The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts.

Authors:  Sandra J Petty; Carol J Milligan; Marian Todaro; Kay L Richards; Pamuditha K Kularathna; Charles N Pagel; Chris R French; Elisa L Hill-Yardin; Terence J O'Brien; John D Wark; Eleanor J Mackie; Steven Petrou
Journal:  Epilepsia       Date:  2016-07-21       Impact factor: 5.864

8.  Bone metabolism alteration on antiepileptic drug therapy.

Authors:  Geetha Krishnamoorthy; Sunil Karande; Nilesh Ahire; Lily Mathew; Madhuri Kulkarni
Journal:  Indian J Pediatr       Date:  2009-02-10       Impact factor: 1.967

9.  Antiepileptic drug use increases rates of bone loss in older women: a prospective study.

Authors:  K E Ensrud; T S Walczak; T Blackwell; E R Ensrud; P J Bowman; K L Stone
Journal:  Neurology       Date:  2004-06-08       Impact factor: 9.910

10.  Effect of Antiepileptic Therapy on Serum 25(OH)D3 and 24,25(OH)2D3 Levels in Epileptic Children.

Authors:  Xin He; Pei Jiang; Wenye Zhu; Ying Xue; Huande Li; Ruili Dang; Hualin Cai; Mimi Tang; Lihong Zhang; Yanqin Wu
Journal:  Ann Nutr Metab       Date:  2016-01-27       Impact factor: 3.374
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  4 in total

1.  Significant Association of Antiepileptic Drug Polytherapy with Decreased FT4 Levels in Epileptic Patients.

Authors:  P K Dabla; S Sharma; R Mir; V Puri
Journal:  Indian J Clin Biochem       Date:  2021-02-04

2.  Osteogenic Effect of Pregabalin in Human Primary Mesenchymal Stem Cells, Osteoblasts, and Osteosarcoma Cells.

Authors:  Nele Wagener; Pietro Di Fazio; Kai Oliver Böker; Georg Matziolis
Journal:  Life (Basel)       Date:  2022-03-28

Review 3.  Vitamin D Deficiency in Older Patients-Problems of Sarcopenia, Drug Interactions, Management in Deficiency.

Authors:  Małgorzata Kupisz-Urbańska; Paweł Płudowski; Ewa Marcinowska-Suchowierska
Journal:  Nutrients       Date:  2021-04-10       Impact factor: 5.717

4.  Parathyroid hormone (1-34) can reverse the negative effect of valproic acid on the osseointegration of titanium rods in ovariectomized rats.

Authors:  Zhou-Shan Tao; Wan-Shu Zhou; Hong-Guang Xu; Min Yang
Journal:  J Orthop Translat       Date:  2020-12-28       Impact factor: 5.191
  4 in total

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