Jung Hun Sung1, Kyuwoong Kim2, Yoosun Cho3, Seulggie Choi2, Jooyoung Chang2, Sung Min Kim2, Seong Rae Kim4, Gyeongsil Lee3, Joung Sik Son3, Sang Min Park5,6. 1. School of Earth and Environmental Sciences, Seoul National University, Seoul, South Korea. 2. Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea. 3. Department of Family Medicine, College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, South Korea. 4. College of Medicine, Seoul National University Hospital, Seoul, South Korea. 5. Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea. smpark.snuh@gmail.com. 6. Department of Family Medicine, College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, South Korea. smpark.snuh@gmail.com.
Abstract
INTRODUCTION: Air particulate matter (PM) is an environmental exposure associated with oxidation and inflammation. Whether particulate matter is associated with risk of osteoporotic bone fracture is unclear. We investigated the association between exposure to PM and risk of bone fractures. MATERIALS AND METHODS: We collected data of 44,602 participants living in three metropolitan cities in Republic of Korea from National Health Insurance Service database. We examined the association of 2 year averaged concentrations of PM and osteoporotic fracture over 4 years. Exposure to 2-year averaged air pollution [PM2.5 (< 2.5 μm in aerodynamic diameter), PM10 [< 10 μm in aerodynamic diameter], PM coarse (PM ranging from 2.5 μm to 10 μm)] concentrations were estimated from 2008 to 2009 in Air Korea data. The adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for osteoporotic fractures were calculated using the multivariate Cox proportional hazards model. RESULTS: After adjusting for age, household income, and Charlson Comorbidity Index, PM 2.5 in one pollutant model increased the risk of osteoporotic fractures, compared to the first quartile group (4th quartile group aHR = 1.13, 95% CI 1.02-1.24). Also, PM 2.5 increased the risk of spine and non-spine fractures compared to the first quartile group (4th quartile group aHR = 1.17, 95% CI 1.00-1.38, aHR = 1.16, 95% CI 1.01-1.33). We found no association between PM10/PM coarse and osteoporotic fractures. CONCLUSION: We found that PM2.5 is a risk factor for osteoporotic bone fractures.
INTRODUCTION: Air particulate matter (PM) is an environmental exposure associated with oxidation and inflammation. Whether particulate matter is associated with risk of osteoporotic bone fracture is unclear. We investigated the association between exposure to PM and risk of bone fractures. MATERIALS AND METHODS: We collected data of 44,602 participants living in three metropolitan cities in Republic of Korea from National Health Insurance Service database. We examined the association of 2 year averaged concentrations of PM and osteoporotic fracture over 4 years. Exposure to 2-year averaged air pollution [PM2.5 (< 2.5 μm in aerodynamic diameter), PM10 [< 10 μm in aerodynamic diameter], PM coarse (PM ranging from 2.5 μm to 10 μm)] concentrations were estimated from 2008 to 2009 in Air Korea data. The adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for osteoporotic fractures were calculated using the multivariate Cox proportional hazards model. RESULTS: After adjusting for age, household income, and Charlson Comorbidity Index, PM 2.5 in one pollutant model increased the risk of osteoporotic fractures, compared to the first quartile group (4th quartile group aHR = 1.13, 95% CI 1.02-1.24). Also, PM 2.5 increased the risk of spine and non-spine fractures compared to the first quartile group (4th quartile group aHR = 1.17, 95% CI 1.00-1.38, aHR = 1.16, 95% CI 1.01-1.33). We found no association between PM10/PM coarse and osteoporotic fractures. CONCLUSION: We found that PM2.5 is a risk factor for osteoporotic bone fractures.
Entities:
Keywords:
Air particulate matter (PM); Long-term exposure; National Health Insurance Data (NHIS); Osteoporotic fracture
Authors: Yoosun Cho; Seulggie Choi; Young Ho Yun; Belong Cho; Ji-Yeob Choi; Sang Min Park Journal: Arch Osteoporos Date: 2021-04-10 Impact factor: 2.617
Authors: Seo Yun Hwang; Seogsong Jeong; Seulggie Choi; Dong Hyun Kim; Seong Rae Kim; Gyeongsil Lee; Joung Sik Son; Sang Min Park Journal: Int J Environ Res Public Health Date: 2021-04-04 Impact factor: 3.390
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