Gholamreza Mohammad Soltani1, Simin Hemati2, Mostafa Sarvizadeh3, Mohammad Kamalinejad4, Vahid Tafazoli5, Seied AmirHossein Latifi6. 1. Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Arak, Iran. Electronic address: Gsoltani@arakmu.ac.ir. 2. Department of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: hematti@med.mui.ac.ir. 3. Department of Radiation Oncology, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: sarvizadeh83@arakmu.ac.ir. 4. School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran. Electronic address: mkamalinejad@sbmu.ac.ir. 5. Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: Stud4469948004@sums.ac.ir. 6. Traditional and Complementary Medicine Research Center (TCMRC), Arak University of Medical Sciences, Arak, Iran. Electronic address: Sah.latifi@arakmu.ac.ir.
Abstract
INTRODUCTION:Oral mucositis is a complication of radiation therapy in cancer patients. We designed a trial to evaluate efficacy of plantago major on symptoms of radiation induced mucositis in cancer patients. METHODS: In this randomized double blind, placebo-controlled trial 23 patients received plantago major syrup as intervention group and 23 patients received placebo syrup as control group for 7 weeks. Outcome measures were severity of mucositis according to WHO scale and severity of patients' pain assessed by visual analogue scale. RESULTS:Severity of mucositis were significantly lower in intervention group compared to placebo group (p value<0.05). Also patients in intervention group experienced significantly less pain compared to placebo group during radiotherapy period (p value<0.05) CONCLUSION:Plantago major L syrup was effective on the reduction of the symptoms of radiation induced mucositis in patients with head and neck cancers.
RCT Entities:
INTRODUCTION:Oral mucositis is a complication of radiation therapy in cancerpatients. We designed a trial to evaluate efficacy of plantago major on symptoms of radiation induced mucositis in cancerpatients. METHODS: In this randomized double blind, placebo-controlled trial 23 patients received plantago major syrup as intervention group and 23 patients received placebo syrup as control group for 7 weeks. Outcome measures were severity of mucositis according to WHO scale and severity of patients' pain assessed by visual analogue scale. RESULTS: Severity of mucositis were significantly lower in intervention group compared to placebo group (p value<0.05). Also patients in intervention group experienced significantly less pain compared to placebo group during radiotherapy period (p value<0.05) CONCLUSION:Plantago major L syrup was effective on the reduction of the symptoms of radiation induced mucositis in patients with head and neck cancers.
Authors: Ana Sofia Ferreira; Catarina Macedo; Ana Margarida Silva; Cristina Delerue-Matos; Paulo Costa; Francisca Rodrigues Journal: Int J Mol Sci Date: 2022-04-15 Impact factor: 6.208