Dear Editor, the recent article “Delirium and sleep disturbances in COVID-19: a possible role for melatonin in hospitalized patients?” is quite noteworthy [1]. Zambrelli et al., mentioned that “Melatonin's safety in doses up to
10 mg has been shown to be very high in ICU patients and should be used in the prevention and treatment of sleep disturbances and delirium in COVID–19.” [1]. The effect of melatonin on novel coronavirus (COVID-19) infection is a significant issue. In brief, melatonin is effective for reducing anxiety and useful for controlling insomnia. Some recent reports mention the benefit of melatonin in management of COVID-19 [2,3]. Melatonin can help decrease lung fibrosis, which is a significant complication of COVID-19 [2,3]. Therefore, it is recommended that melatonin should be used in any COVID-19 cases regardless of delirium or sleep disturbance.