Hyun Ae Jung1, Jae Myoung Noh2, Jong-Mu Sun1, Se-Hoon Lee1, Jin Seok Ahn1, Myung-Ju Ahn1, Hongryull Pyo2, Yong Chan Ahn2, Keunchil Park3. 1. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 2. Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 3. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address: kpark@skku.edu.
Abstract
OBJECTIVES: The PACIFIC study demonstrated the benefits of durvalumab consolidation on progression-free survival (PFS) and overall survival (OS) among patients with unresectable locally advanced non-small-cell lung cancer (LA-NSCLC). However, in real-world practice, patients with unresectable LA-NSCLC are heterogeneous with diverse tumor burdens and clinical factors; thus, it is important to examine the effectiveness and side effects of durvalumab when used in real clinical practice. MATERIALS AND METHODS: We investigated the efficacy of durvalumab consolidation and the incidence of radiation pneumonitis in patients who received concurrent chemo-radiotherapy (CCRT) for unresectable LA-NSCLC in a single institute. RESULTS: Overall, 55.3 % of patients did not meet the criteria of the PACIFIC study; however, they still received consolidation durvalumab in real-world practice. Durvalumab consolidation was associated with favorable PFS in the total population as well as in the subgroup of patients who did not meet the criteria of the PACIFIC study. However, radiation pneumonitis occurred more frequently in the durvalumab group, especially within 3-6 months after CCRT. The incidence of grade 3 radiation pneumonitis was 14.3 % in the durvalumab group versus 2.5 % in the observation group. CONCLUSIONS: Durvalumab consolidation was associated with favorable PFS in patients with LA-NSCLC in clinical practice. However, careful selection of candidates for durvalumab treatment and active surveillance and appropriate management for radiation pneumonitis are needed.
OBJECTIVES: The PACIFIC study demonstrated the benefits of durvalumab consolidation on progression-free survival (PFS) and overall survival (OS) among patients with unresectable locally advanced non-small-cell lung cancer (LA-NSCLC). However, in real-world practice, patients with unresectable LA-NSCLC are heterogeneous with diverse tumor burdens and clinical factors; thus, it is important to examine the effectiveness and side effects of durvalumab when used in real clinical practice. MATERIALS AND METHODS: We investigated the efficacy of durvalumab consolidation and the incidence of radiation pneumonitis in patients who received concurrent chemo-radiotherapy (CCRT) for unresectable LA-NSCLC in a single institute. RESULTS: Overall, 55.3 % of patients did not meet the criteria of the PACIFIC study; however, they still received consolidation durvalumab in real-world practice. Durvalumab consolidation was associated with favorable PFS in the total population as well as in the subgroup of patients who did not meet the criteria of the PACIFIC study. However, radiation pneumonitis occurred more frequently in the durvalumab group, especially within 3-6 months after CCRT. The incidence of grade 3 radiation pneumonitis was 14.3 % in the durvalumab group versus 2.5 % in the observation group. CONCLUSIONS:Durvalumab consolidation was associated with favorable PFS in patients with LA-NSCLC in clinical practice. However, careful selection of candidates for durvalumab treatment and active surveillance and appropriate management for radiation pneumonitis are needed.
Authors: Tithi Biswas; Afshin Dowlati; Charles A Kunos; John J Pink; Nancy L Oleinick; Shakun Malik; Pingfu Fu; Shufen Cao; Debora S Bruno; David L Bajor; Monaliben Patel; Stanton L Gerson; Mitchell Machtay Journal: Clin Cancer Res Date: 2022-02-15 Impact factor: 13.801
Authors: Merle I Ronden; Idris Bahce; Niels J M Claessens; Nicole Barlo; Max R Dahele; Johannes M A Daniels; Caroline Tissing-Tan; Edo Hekma; Sayed M S Hashemi; Antoinet van der Wel; Femke O B Spoelstra; Wilko F A R Verbakel; Marian A Tiemessen; Marjolein van Laren; Annemarie Becker; Svitlana Tarasevych; Cornelis J A Haasbeek; Karen Maassen van den Brink; Chris Dickhoff; Suresh Senan Journal: JTO Clin Res Rep Date: 2021-06-06