Jean Lowe1, Carla M Bann2, Janell Fuller3, Betty R Vohr4, Susan R Hintz5, Abhik Das6, Rosemary D Higgins7, Kristi L Watterberg1. 1. University of New Mexico Health Sciences Center, Albuquerque, NM, USA. 2. Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC, USA. 3. University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Electronic address: jafuller@salud.unm.edu. 4. Department of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI, USA. 5. Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA. 6. Social, Statistical and Environmental Sciences Unit, RTI International, Bethesda, MD, USA. 7. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Abstract
OBJECTIVE: The study was designed to investigate whether attainment of object permanence, a measure of early working memory used at 18-22 months corrected age, was associated with executive function at 6-7 years in a cohort of children born extremely preterm. STUDY DESIGN: Children enrolled in the Neuroimaging and Neurodevelopmental Outcome (NEURO) study, a secondary study to the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) of the NICHD NRN, were eligible for this longitudinal study. Testing completed at 18 to 22 months corrected age was compared to testing at school age with a specific focus on measures of executive function. RESULTS: Children who had achieved object permanence mastery at a corrected age of 18-22 months had higher mean scores on the WISC-IV tests of verbal comprehension and processing speed at age 6-7 years. Regression models indicated that object permanence scores were significant predictors of both verbal comprehension and processing speeds scores, after controlling for other factors. When analyzed by subgroup for sex, these results were significant for girls but not for boys. CONCLUSIONS: This study found that an early mastery of object permanence was associated with higher scores in areas of verbal comprehension and processing speed in girls. These results have implications for potentially identifying young children born preterm that are at greater risk for difficulties with cognitive and working memory skills at school age.
OBJECTIVE: The study was designed to investigate whether attainment of object permanence, a measure of early working memory used at 18-22 months corrected age, was associated with executive function at 6-7 years in a cohort of children born extremely preterm. STUDY DESIGN: Children enrolled in the Neuroimaging and Neurodevelopmental Outcome (NEURO) study, a secondary study to the Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) of the NICHD NRN, were eligible for this longitudinal study. Testing completed at 18 to 22 months corrected age was compared to testing at school age with a specific focus on measures of executive function. RESULTS: Children who had achieved object permanence mastery at a corrected age of 18-22 months had higher mean scores on the WISC-IV tests of verbal comprehension and processing speed at age 6-7 years. Regression models indicated that object permanence scores were significant predictors of both verbal comprehension and processing speeds scores, after controlling for other factors. When analyzed by subgroup for sex, these results were significant for girls but not for boys. CONCLUSIONS: This study found that an early mastery of object permanence was associated with higher scores in areas of verbal comprehension and processing speed in girls. These results have implications for potentially identifying young children born preterm that are at greater risk for difficulties with cognitive and working memory skills at school age.
Authors: Peter J Anderson; Katherine J Lee; Gehan Roberts; Megan M Spencer-Smith; Deanne K Thompson; Marc L Seal; Chiara Nosarti; Andrea Grehan; Elisha K Josev; Susan Gathercole; Lex W Doyle; Leona Pascoe Journal: J Pediatr Date: 2018-08-31 Impact factor: 4.406
Authors: Robin K Ohls; Beena D Kamath-Rayne; Robert D Christensen; Susan E Wiedmeier; Adam Rosenberg; Janell Fuller; Conra Backstrom Lacy; Mahshid Roohi; Diane K Lambert; Jill J Burnett; Barbara Pruckler; Hannah Peceny; Daniel C Cannon; Jean R Lowe Journal: Pediatrics Date: 2014-05-12 Impact factor: 7.124
Authors: Danielle S Costa; Débora M Miranda; Alice C Burnett; Lex W Doyle; Jeanie L Y Cheong; Peter J Anderson Journal: Pediatrics Date: 2017-09 Impact factor: 7.124
Authors: S Horsch; B Skiöld; B Hallberg; B Nordell; A Nordell; M Mosskin; H Lagercrantz; U Adén; M Blennow Journal: Arch Dis Child Fetal Neonatal Ed Date: 2009-10-19 Impact factor: 5.747