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Literature DB >> 3250370

Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.

G Grimmer¹, H Brune, G Dettbarn, U Heinrich, J Jacob, E Mohtashamipur, K Norpoth, F Pott, R Wenzel-Hartung.

Abstract

The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of administration. In all cases the oxidation of chrysene in the 1,2- or 3,4-position predominates, whereas oxidation in the 5,6-position (K-region) seems be a minor pathway.

Entities: Chemical Species

Mesh：

Substances：
Chrysenes
Phenanthrenes

Year: 1988 PMID： 3250370 DOI： 10.1007/bf00288341

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

18 in total

1. The metabolism of chrysene: the isolation of 3-methoxychrysene by methylation of the phenolic metabolite of chrysene from rat faeces.

Authors: I Berenblum; R Schoental
Journal: Biochem J Date: 1949 Impact factor: 3.857

Review 2. Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis.

Authors: P Sims; P L Grover
Journal: Adv Cancer Res Date: 1974 Impact factor: 6.242

3. Experimental induction of epidermoid carcinoma in the lungs of rats by cigarette smoke condensate.

Authors: M F Stanton; E Miller; C Wrench; R Blackwell
Journal: J Natl Cancer Inst Date: 1972-09 Impact factor: 13.506

4. A method for the experimental induction of bronchogenic carcinoma.

Authors: U Saffiotti; F Cefis; L H Kolb
Journal: Cancer Res Date: 1968-01 Impact factor: 12.701

5. Qualitative and quantitative studies on the metabolism of a series of aromatic hydrocarbons by rat-liver preparations.

Authors: P Sims
Journal: Biochem Pharmacol Date: 1970-03 Impact factor: 5.858

6. Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-1,2-dihydroxy-1,2-dihydrochrysene to bay-region 1,2-diol-3,4-epoxide diastereomers by rat liver enzymes.

Authors: K P Vyas; W Levin; H Yagi; D R Thakker; D E Ryan; P E Thomas; A H Conney; D M Jerina
Journal: Mol Pharmacol Date: 1982-07 Impact factor: 4.436

Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.

1. The metabolism of chrysene: the isolation of 3-methoxychrysene by methylation of the phenolic metabolite of chrysene from rat faeces.

Review 2. Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis.

3. Experimental induction of epidermoid carcinoma in the lungs of rats by cigarette smoke condensate.

4. A method for the experimental induction of bronchogenic carcinoma.

5. Qualitative and quantitative studies on the metabolism of a series of aromatic hydrocarbons by rat-liver preparations.

6. Stereoselective metabolism of the (+)- and (-)-enantiomers of trans-1,2-dihydroxy-1,2-dihydrochrysene to bay-region 1,2-diol-3,4-epoxide diastereomers by rat liver enzymes.

7. Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.

8. Metabolic activation of chrysene in mouse skin: evidence for the involvement of a triol-epoxide.

9. METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 9,10-EPOXY-9,10-DIHYDROPHENANTHRENE IN RATS.

10. The formation of 9-hydroxychrysene-1,2-diol as an intermediate in the metabolic activation of chrysene.

1. Vehicle-dependent disposition kinetics of fluoranthene in Fisher-344 rats.