| Literature DB >> 32502860 |
Aimée R Kreimer1, Anil K Chaturvedi2, Laia Alemany3, Devasena Anantharaman4, Freddie Bray5, Mary Carrington6, John Doorbar7, Gypsyamber D'Souza8, Carole Fakhry9, Robert L Ferris10, Maura Gillison11, D Neil Hayes12, Allan Hildesheim13, Shao Hui Huang14, Luiz P Kowalski15, Krystle A Lang Kuhs16, James Lewis17, Douglas R Lowy18, Hisham Mehanna19, Andy Ness20, Michael Pawlita21, Maisa Pinheiro22, John Schiller23, Meredith S Shiels24, Joseph Tota25, Lisa Mirabello26, Saman Warnakulasuriya27, Tim Waterboer28, William Westra29, Stephen Chanock30, Paul Brennan31.
Abstract
Cancer of the oropharynx has attracted considerable attention in recent years given: (1) an increasing incidence in selected populations over the past three decades; (2) the discovery of human papillomavirus (HPV) infection as the driver of the increase, as opposed to the traditional risk factors such as tobacco (smoking and chewing) and alcohol; and (3) the promise of new prevention and treatment strategies. As a result of such developments, the International Agency for Research on Cancer (IARC) and the US National Cancer Institute (NCI), convened the fourth Cancer Seminar meeting in November 2018 to focus on this topic. This report summarizes the proceedings: a review of recent science on the descriptive epidemiology, etiology, biology, genetics, early detection, pathology and treatment of HPV-positive oropharyngeal cancer, and the formulation of key research questions to be addressed. Published by Elsevier Ltd.Entities:
Keywords: Etiology; Genetics; HPV; Oropharynx cancer; Prevention; Screening; Therapy
Mesh：
Year: 2020 PMID： 32502860 PMCID： PMC7909748 DOI： 10.1016/j.oraloncology.2020.104736
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337