Victoria Barber1, Anna Calvert2,3, Tushna Vandrevala1, Caroline Star1, Asma Khalil3,4, Paul Griffiths5, Paul T Heath2,3, Christine E Jones2,3,6. 1. From the Department of Psychology, Kingston University. 2. Paediatric Infectious Diseases Research Group, St George's University of London. 3. St George's University Hospitals NHS Foundation Trust. 4. Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London. 5. University College London, Medical School, Institute of Immunity and Transplantation, London. 6. Faculty of Medicine and Institute for Life Sciences, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
Abstract
BACKGROUND: Congenital cytomegalovirus infection is the most common nongenetic cause of sensorineural hearing loss in childhood and an important cause of neurodisability. There is no licensed cytomegalovirus (CMV) vaccine and no antenatal treatment for congenital CMV that is routinely recommended in clinical practice in the United Kingdom. OBJECTIVES: To review the published literature for studies that evaluated preventative hygiene-based interventions in pregnancy for their impact on knowledge about CMV prevention, the uptake of preventative behaviors or the acquisition of CMV in pregnancy. SEARCH STRATEGY: Searches were carried out in Medical Literature Analysis and Retrieval System Online and Cumulative Index of Nursing and Allied Health Literature databases. SELECTION CRITERIA: All human studies, limited to women of childbearing age were included. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed the quality of the methods and results of included articles. Extracted data were classified using Cochrane guidelines. MAIN RESULTS: Seven studies met the inclusion criteria. These show that preventative measures are acceptable to pregnant women, can impact their behavior and have the potential to reduce CMV in pregnancy. They are limited by several factors; sample size, nonrandomized trial design and interventions that are beyond routine clinical practice. CONCLUSIONS: An effective intervention that changes behavior in pregnancy and reduces the risk of CMV acquisition is needed as part of routine care. There is currently insufficient evidence about the form that this intervention should take. REGISTRATION: PROSPERO registration number: CRD42017069666.
BACKGROUND:Congenital cytomegalovirus infection is the most common nongenetic cause of sensorineural hearing loss in childhood and an important cause of neurodisability. There is no licensed cytomegalovirus (CMV) vaccine and no antenatal treatment for congenital CMV that is routinely recommended in clinical practice in the United Kingdom. OBJECTIVES: To review the published literature for studies that evaluated preventative hygiene-based interventions in pregnancy for their impact on knowledge about CMV prevention, the uptake of preventative behaviors or the acquisition of CMV in pregnancy. SEARCH STRATEGY: Searches were carried out in Medical Literature Analysis and Retrieval System Online and Cumulative Index of Nursing and Allied Health Literature databases. SELECTION CRITERIA: All human studies, limited to women of childbearing age were included. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed the quality of the methods and results of included articles. Extracted data were classified using Cochrane guidelines. MAIN RESULTS: Seven studies met the inclusion criteria. These show that preventative measures are acceptable to pregnant women, can impact their behavior and have the potential to reduce CMV in pregnancy. They are limited by several factors; sample size, nonrandomized trial design and interventions that are beyond routine clinical practice. CONCLUSIONS: An effective intervention that changes behavior in pregnancy and reduces the risk of CMV acquisition is needed as part of routine care. There is currently insufficient evidence about the form that this intervention should take. REGISTRATION: PROSPERO registration number: CRD42017069666.
Authors: Anna Calvert; Tushna Vandrevala; Robin Parsons; Victoria Barber; Alex Book; Gayle Book; David Carrington; Vanessa Greening; Paul Griffiths; Danielle Hake; Asma Khalil; Suzanne Luck; Amy Montague; Caroline Star; Irina Chis Ster; Sharon Wood; Paul T Heath; Christine E Jones Journal: BMC Pregnancy Childbirth Date: 2021-08-18 Impact factor: 3.007
Authors: Paddy Ssentongo; Christine Hehnly; Patricia Birungi; Mikayla A Roach; Jada Spady; Claudio Fronterre; Ming Wang; Laura E Murray-Kolb; Laila Al-Shaar; Vernon M Chinchilli; James R Broach; Jessica E Ericson; Steven J Schiff Journal: JAMA Netw Open Date: 2021-08-02
Authors: Amy Montague; Tushna Vandrevala; Anna Calvert; I-Ling Yeh; Caroline Star; Asma Khalil; Paul Griffiths; Paul T Heath; Christine E Jones Journal: Midwifery Date: 2022-01-06 Impact factor: 2.372