Binqi Li1,2, Anping Wang1, Yuxia Wang3, Lin Li4, Bing Li1, Zizhong Yang1,2, Xin Zhou1, Zhengnan Gao5, Xulei Tang6, Li Yan7, Qin Wan8, Weiqing Wang9, Guijun Qin10, Lulu Chen11, Guang Ning9, Yiming Mu1. 1. Chinese PLA General Hospital, Beijing, China. 2. School of Medicine, Nankai University, Tianjin, China. 3. Beijing Friendship Hospital, Capital Medical University, Beijing, China. 4. The PLA Rocket Force Characteristic Medical Center, Beijing, China. 5. Dalian Municipal Central Hospital, Dalian, China. 6. First Hospital of Lanzhou University, Lanzhou, China. 7. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. 8. Affiliated Hospital of Luzhou Medical College, Luzhou, China. 9. Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 10. First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 11. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Abstract
BACKGROUND: The correlation between remnant cholesterol (RC) and urinary albumin to creatinine ratio (UACR) has not been illustrated. The present study aims to explore the correlation between RC levels and UACR in Chinese community adults. METHODS: This study included 35 848 participants from a cohort study (REACTION). The UACR data were divided into three groups: UACR <10 mg/g, 10 ≤UACR<30 mg/g, and UACR ≥30 mg/g groups. RC was divided into two groups, according to the 75th percentile: <75% group and ≥75% group. Multiple logistic regression analysis was used to evaluate the correlation between RC and UACR. RESULTS: The RC exhibited an adjusted odds ratio that was significant in models 1-5. Although all confounders were corrected in model 5, RC and UACR were still significantly correlated， and the correlation was more significant in females，when compared to males (odds ratio [OR]: 1.117, 95% CI: 1.063-1.176, P < 0.001 for all subjects; OR: 1.092, 95% CI: 1.128-1.161, P = 0.004 for females; and OR: 1.085, 95% CI: 0.998-1.194, P = 0.088 for males). The RC was significantly correlated with UACR for subjects with 5.6 ≤ fasting blood glucose < 7.0 or 7.8 ≤ post-load blood glucose < 11.1 mmol/L, 24 ≤ body mass index (BMI) < 28 kg/m2 , 120 ≤ systolic blood pressure < 140 and/or 80 ≤ diastolic blood pressure < 90 mm Hg. CONCLUSIONS: In the Chinese community, RC is highly correlated with UACR, and the correlation is more significant in females compared with males. At higher RC levels, patients with critical values of blood pressure, BMI and blood glucose have a more significant correlation between RC and UACR.
BACKGROUND: The correlation between remnant cholesterol (RC) and urinary albumin to creatinine ratio (UACR) has not been illustrated. The present study aims to explore the correlation between RC levels and UACR in Chinese community adults. METHODS: This study included 35 848 participants from a cohort study (REACTION). The UACR data were divided into three groups: UACR <10 mg/g, 10 ≤UACR<30 mg/g, and UACR ≥30 mg/g groups. RC was divided into two groups, according to the 75th percentile: <75% group and ≥75% group. Multiple logistic regression analysis was used to evaluate the correlation between RC and UACR. RESULTS: The RC exhibited an adjusted odds ratio that was significant in models 1-5. Although all confounders were corrected in model 5, RC and UACR were still significantly correlated， and the correlation was more significant in females，when compared to males (odds ratio [OR]: 1.117, 95% CI: 1.063-1.176, P < 0.001 for all subjects; OR: 1.092, 95% CI: 1.128-1.161, P = 0.004 for females; and OR: 1.085, 95% CI: 0.998-1.194, P = 0.088 for males). The RC was significantly correlated with UACR for subjects with 5.6 ≤ fasting blood glucose < 7.0 or 7.8 ≤ post-load blood glucose < 11.1 mmol/L, 24 ≤ body mass index (BMI) < 28 kg/m2 , 120 ≤ systolic blood pressure < 140 and/or 80 ≤ diastolic blood pressure < 90 mm Hg. CONCLUSIONS: In the Chinese community, RC is highly correlated with UACR, and the correlation is more significant in females compared with males. At higher RC levels, patients with critical values of blood pressure, BMI and blood glucose have a more significant correlation between RC and UACR.