| Literature DB >> 32500474 |
Lingyu Song1,2, Yan Wang3,2, Yunhuan Zhen4, Dengke Li1, Xidong He1, Hong Yang1, Huayang Zhang1, Qi Liu5,6.
Abstract
Cancer metastasis is the primary cause of death in patients diagnosed with colorectal cancer. Piperine, an active nontoxic ingredient in pepper, has potent anti-inflammatory and anti-cancer properties. However, little is known about the anti-migratory and anti-invasive effects of piperine on colorectal cancer. We demonstrated piperine inhibited the migration and invasion of colorectal cancer cells. Then, we found piperine reversed the biomarker expression of epithelial-to-mesenchymal transition (EMT), and suppressed the EMT regulator Snail. Furthermore, signal transducers and activators of transcription 3 (STAT3) was downregulated by piperine. Finally, STAT3 inhibitors were applied to observe the role of STAT3 in colorectal cancer migration, invasion and EMT. Collectively, piperine inhibits colorectal cancer migratory and invasive capacities through STAT3/Snail mediated EMT. Therefore, piperine could be applied as a possible therapeutic regimen for the prevention of colorectal cancer metastasis.Entities:
Keywords: Colorectal cancer; Epithelial–mesenchymal transition; Metastasis; Piperine; STAT3
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Year: 2020 PMID： 32500474 DOI： 10.1007/s10529-020-02923-z
Source DB: PubMed Journal: Biotechnol Lett ISSN： 0141-5492 Impact factor: 2.461