Young Kook Kim1,2, Ki Ho Park3,4, Eunoo Bak5,6, Won June Lee7, Jin-Soo Kim5,6, Jinho Lee5,6, Ahnul Ha5,6, Yong Woo Kim5,6, Michael J A Girard8,9, Jean Martial Mari10, Jin Wook Jeoung5,6. 1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea. md092@naver.com. 2. Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. md092@naver.com. 3. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea. kihopark@snu.ac.kr. 4. Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. kihopark@snu.ac.kr. 5. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea. 6. Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea. 7. Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea. 8. Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore. 9. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. 10. University of French Polynesia, Tahiti, French Polynesia.
Abstract
PURPOSE: To investigate the association between the laminar dot sign (LDS) and the deep optic nerve head (ONH) structure in eyes with primary-open-angle glaucoma (POAG). METHODS: Eighty-four eyes of 84 patients with POAG were prospectively included. All of the patients underwent stereo optic disc photography (SDP), red-free retinal nerve fibre layer (RNFL) photography, SS-OCT, and standard automated perimetry. By evaluating the SDP, patients were classified into laminar dot sign (LDS) and non-LDS groups. The deep structure of the ONH including the anterior prelaminar depth (APLD) and prelaminar tissue thickness (PTT) were quantitated using SS-OCT. Progression was assessed by structural or functional deterioration during the average 4.3 ± 1.2 years of follow-up. RESULTS: The LDS group had deeper APLD (405.47 ± 107.55 vs. 302.45 ± 149.51, P < 0.001) and thinner PTT (74.34 ± 24.46 vs. 137.29 ± 40.07, P = 0.001) relative to the non-LDS group. By multivariate analysis, thin PTT was significantly associated with the presence of LDS (odds ratio = 0.939, P < 0.001). Structural progression was detected in 45 eyes (84.9%) in the LDS group and 8 eyes (25.8%) in the non-LDS group. Functional progression was demonstrated in 29 eyes (34.5%) in the LDS group and 6 eyes (19.4%) in the non-LDS group. The eyes with LDS had a significantly higher risk of glaucoma progression (χ2 = 5.00, degree of freedom = 1, P = 0.033). CONCLUSIONS: In eyes with POAG, the presence of LDS was associated with thinner prelaminar tissue and faster disease progression.
PURPOSE: To investigate the association between the laminar dot sign (LDS) and the deep optic nerve head (ONH) structure in eyes with primary-open-angle glaucoma (POAG). METHODS: Eighty-four eyes of 84 patients with POAG were prospectively included. All of the patients underwent stereo optic disc photography (SDP), red-free retinal nerve fibre layer (RNFL) photography, SS-OCT, and standard automated perimetry. By evaluating the SDP, patients were classified into laminar dot sign (LDS) and non-LDS groups. The deep structure of the ONH including the anterior prelaminar depth (APLD) and prelaminar tissue thickness (PTT) were quantitated using SS-OCT. Progression was assessed by structural or functional deterioration during the average 4.3 ± 1.2 years of follow-up. RESULTS: The LDS group had deeper APLD (405.47 ± 107.55 vs. 302.45 ± 149.51, P < 0.001) and thinner PTT (74.34 ± 24.46 vs. 137.29 ± 40.07, P = 0.001) relative to the non-LDS group. By multivariate analysis, thin PTT was significantly associated with the presence of LDS (odds ratio = 0.939, P < 0.001). Structural progression was detected in 45 eyes (84.9%) in the LDS group and 8 eyes (25.8%) in the non-LDS group. Functional progression was demonstrated in 29 eyes (34.5%) in the LDS group and 6 eyes (19.4%) in the non-LDS group. The eyes with LDS had a significantly higher risk of glaucoma progression (χ2 = 5.00, degree of freedom = 1, P = 0.033). CONCLUSIONS: In eyes with POAG, the presence of LDS was associated with thinner prelaminar tissue and faster disease progression.
Authors: Alexandra Trivli; Ioannis Koliarakis; Chryssa Terzidou; George N Goulielmos; Charalambos S Siganos; Demetrios A Spandidos; Georgios Dalianis; Efstathios T Detorakis Journal: Exp Ther Med Date: 2018-11-26 Impact factor: 2.447