Mohammad-Parsa Hosseini1, Tuyen X Tran2, Dario Pompili2, Kost Elisevich3, Hamid Soltanian-Zadeh4. 1. Department of Electrical and Computer Engineering, Rutgers University, NJ, USA; Department of Bioengineering, Santa Clara University, CA, USA; AI Research, Silicon Valley, CA, USA. Electronic address: parsa@cac.rutgers.edu. 2. Department of Electrical and Computer Engineering, Rutgers University, NJ, USA. 3. Division of Neurosurgery, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA; Dept. of Clinical Neurosciences, Spectrum Health, Grand Rapids, MI, USA. 4. CIPCE, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran; Image Analysis Lab, Depts. of Radiology and Research Administration, Henry Ford Health System, MI, USA.
Abstract
BACKGROUND AND OBJECTIVE: Multimodal data analysis and large-scale computational capability is entering medicine in an accelerative fashion and has begun to influence investigational work in a variety of disciplines. It is also informing us of therapeutic interventions that will come about with such development. Epilepsy is a chronic brain disorder in which functional changes may precede structural ones and which may be detectable using existing modalities. METHODS: Functional connectivity analysis using electroencephalography (EEG) and resting state-functional magnetic resonance imaging (rs-fMRI) has provided such meaningful input in cases of epilepsy. By leveraging the potential of autonomic edge computing in epilepsy, we develop and deploy both noninvasive and invasive methods for monitoring, evaluation, and regulation of the epileptic brain. First, an autonomic edge computing framework is proposed for the processing of big data as part of a decision support system for surgical candidacy. Second, a multimodal data analysis using independently acquired EEG and rs-fMRI is presented for estimation and prediction of the epileptogenic network. Third, an unsupervised feature extraction model is developed for EEG analysis and seizure prediction based on a Convolutional deep learning (CNN) structure for distinguishing preictal (pre-seizure) state from non-preictal periods by support vector machine (SVM) classifier. RESULTS: Experimental and simulation results from actual patient data validate the effectiveness of the proposed methods. CONCLUSIONS: The combination of rs-fMRI and EEG/iEEG can reveal more information about dynamic functional connectivity. However, simultaneous fMRI and EEG data acquisition present challenges. We have proposed system models for leveraging and processing independently acquired fMRI and EEG data.
BACKGROUND AND OBJECTIVE: Multimodal data analysis and large-scale computational capability is entering medicine in an accelerative fashion and has begun to influence investigational work in a variety of disciplines. It is also informing us of therapeutic interventions that will come about with such development. Epilepsy is a chronic brain disorder in which functional changes may precede structural ones and which may be detectable using existing modalities. METHODS: Functional connectivity analysis using electroencephalography (EEG) and resting state-functional magnetic resonance imaging (rs-fMRI) has provided such meaningful input in cases of epilepsy. By leveraging the potential of autonomic edge computing in epilepsy, we develop and deploy both noninvasive and invasive methods for monitoring, evaluation, and regulation of the epileptic brain. First, an autonomic edge computing framework is proposed for the processing of big data as part of a decision support system for surgical candidacy. Second, a multimodal data analysis using independently acquired EEG and rs-fMRI is presented for estimation and prediction of the epileptogenic network. Third, an unsupervised feature extraction model is developed for EEG analysis and seizure prediction based on a Convolutional deep learning (CNN) structure for distinguishing preictal (pre-seizure) state from non-preictal periods by support vector machine (SVM) classifier. RESULTS: Experimental and simulation results from actual patient data validate the effectiveness of the proposed methods. CONCLUSIONS: The combination of rs-fMRI and EEG/iEEG can reveal more information about dynamic functional connectivity. However, simultaneous fMRI and EEG data acquisition present challenges. We have proposed system models for leveraging and processing independently acquired fMRI and EEG data.
Authors: Nykan Mirchi; Nebras M Warsi; Frederick Zhang; Simeon M Wong; Hrishikesh Suresh; Karim Mithani; Lauren Erdman; George M Ibrahim Journal: Front Hum Neurosci Date: 2022-06-27 Impact factor: 3.473