BACKGROUND AND OBJECTIVE: The effects of corticosteroid treatment on non-severe COVID-19 pneumonia patients are unknown. To determine the impacts of adjuvant corticosteroid administrated to patients with non-severe COVID-19 pneumonia. METHOD: A retrospective cohort study based on propensity score analysis was designed to explore the effects of corticosteroid on several clinical outcomes. RESULTS: One hundred thirty-two patients satisfied the inclusion criteria and 35 pairs were generated according to propensity score matching. Compared to non-corticosteroid group, the CT score on day 7 was significantly higher in corticosteroid group (8.6 (interquartile range [IQR], 2.8-11.5) versus 12.0 (IQR, 5.0-19.3), P = 0.046). In corticosteroid group, more patients progressed to severe cases (11.4% versus 2.9%, P = 0.353), hospital stay (23.5 days (IQR, 19-29 d) versus 20.2 days (IQR, 14-25.3 d), P = 0.079) and duration of viral shedding (20.3 days (IQR, 15.2-24.8 d) versus 19.4 days (IQR, 11.5-28.3 d), P = 0.669) were prolonged, while fever time (9.5 days (IQR, 6.5-12.2 d) versus 10.2 days (IQR, 6.8-14 d), P = 0.28) was shortened; however, all these data revealed no statistically significant differences. CONCLUSION: Corticosteroid might have a negative effect on lung injury recovery in non-severe COVID-19 pneumonia patients; however, the results of this study must be interpreted with caution because of confounding factors.
BACKGROUND AND OBJECTIVE: The effects of corticosteroid treatment on non-severe COVID-19 pneumoniapatients are unknown. To determine the impacts of adjuvant corticosteroid administrated to patients with non-severe COVID-19 pneumonia. METHOD: A retrospective cohort study based on propensity score analysis was designed to explore the effects of corticosteroid on several clinical outcomes. RESULTS: One hundred thirty-two patients satisfied the inclusion criteria and 35 pairs were generated according to propensity score matching. Compared to non-corticosteroid group, the CT score on day 7 was significantly higher in corticosteroid group (8.6 (interquartile range [IQR], 2.8-11.5) versus 12.0 (IQR, 5.0-19.3), P = 0.046). In corticosteroid group, more patients progressed to severe cases (11.4% versus 2.9%, P = 0.353), hospital stay (23.5 days (IQR, 19-29 d) versus 20.2 days (IQR, 14-25.3 d), P = 0.079) and duration of viral shedding (20.3 days (IQR, 15.2-24.8 d) versus 19.4 days (IQR, 11.5-28.3 d), P = 0.669) were prolonged, while fever time (9.5 days (IQR, 6.5-12.2 d) versus 10.2 days (IQR, 6.8-14 d), P = 0.28) was shortened; however, all these data revealed no statistically significant differences. CONCLUSION: Corticosteroid might have a negative effect on lung injury recovery in non-severe COVID-19 pneumoniapatients; however, the results of this study must be interpreted with caution because of confounding factors.
Authors: José Luis Piñana; Rodrigo Martino; Irene García-García; Rocío Parody; María Dolores Morales; Gonzalo Benzo; Irene Gómez-Catalan; Rosa Coll; Ignacio De La Fuente; Alejandro Luna; Beatriz Merchán; Anabelle Chinea; Dunia de Miguel; Ana Serrano; Carmen Pérez; Carola Diaz; José Luis Lopez; Adolfo Jesús Saez; Rebeca Bailen; Teresa Zudaire; Diana Martínez; Manuel Jurado; María Calbacho; Lourdes Vázquez; Irene Garcia-Cadenas; Laura Fox; Ana I Pimentel; Guiomar Bautista; Agustin Nieto; Pascual Fernandez; Juan Carlos Vallejo; Carlos Solano; Marta Valero; Ildefonso Espigado; Raquel Saldaña; Luisa Sisinni; Josep Maria Ribera; Maria Jose Jimenez; Maria Trabazo; Marta Gonzalez-Vicent; Noemí Fernández; Carme Talarn; Maria Carmen Montoya; Angel Cedillo; Anna Sureda Journal: Exp Hematol Oncol Date: 2020-08-25
Authors: Matteo Bassetti; Daniele Roberto Giacobbe; Paolo Bruzzi; Emanuela Barisione; Stefano Centanni; Nadia Castaldo; Silvia Corcione; Francesco Giuseppe De Rosa; Fabiano Di Marco; Andrea Gori; Andrea Gramegna; Guido Granata; Angelo Gratarola; Alberto Enrico Maraolo; Malgorzata Mikulska; Andrea Lombardi; Federico Pea; Nicola Petrosillo; Dejan Radovanovic; Pierachille Santus; Alessio Signori; Emanuela Sozio; Elena Tagliabue; Carlo Tascini; Carlo Vancheri; Antonio Vena; Pierluigi Viale; Francesco Blasi Journal: Infect Dis Ther Date: 2021-07-30
Authors: Jong Hoon Hyun; Moo Hyun Kim; Yujin Sohn; Yunsuk Cho; Yae Jee Baek; Jung Ho Kim; Jin Young Ahn; Jun Yong Choi; Joon Sup Yeom; Mi Young Ahn; Eun Jin Kim; Ji-Hyeon Baek; Young Keun Kim; Heun Choi; Su Jin Jeong Journal: BMC Infect Dis Date: 2021-05-31 Impact factor: 3.090