Tim Kambič1, Marko Novaković, Katja Tomažin, Vojko Strojnik, Mojca Božič-Mijovski, Borut Jug. 1. Tim Kambič, MKin Research Fellow, Department of Research, and Education, General Hospital Murska Sobota, Murska Sobota, and PhD Student, Faculty of Sport, University of Ljubljana, Slovenia. Marko Novakovič, MD, PhD Research Fellow and Resident, Department of Vascular Diseases, Division of Internal Medicine, University Medical Centre Ljubljana, Slovenia. Katja Tomažin, PhD Associate Professor of Kinesiology, Faculty of Sport, University of Ljubljana, Ljubljana, Slovenia. Vojko Strojnik, PhD Professor, Faculty of Sport, University of Ljubljana, Slovenia. Mojca Božič-Mijovski, PhD Assistant Professor, Laboratory for Haemostasis and Atherothrombosis, Department of Vascular Diseases, University Medical Centre Ljubljana, Slovenia. Borut Jug, MD, PhD Associate Professor of Medicine, Department of Vascular Diseases, Division of Internal Medicine, University Medical Centre Ljubljana, and Faculty of Medicine, University of Ljubljana, Slovenia.
Abstract
BACKGROUND:Blood flow-restricted resistance training (BFR-RT) has been proven to be safe and efficacious in healthy older adults, but not in cardiovascular disease. OBJECTIVE: The aim of this study was to investigate the acute and training induced effects of BFR-RT on hemostatic and hemodynamic responses in patients with coronary artery disease (CAD). METHODS:Stable patients with CAD were randomized to 8 weeks of BFR-RT (30%-40% 1-repetition maximum unilateral knee extension) combined with aerobic training or aerobic training alone (control group). At baseline and after 4 and 8 weeks, blood samples were taken before and after BFR exercise, whereas hemodynamic parameters were monitored throughout the exercise. RESULTS:Twenty-four patients (12 per group; mean age, 60 ± 2 years; mostly male [75%]) completed the study. The BFR-RT significantly improved systolic blood pressure (-10 mm Hg; P = .020) and tended to lower diastolic blood pressure (-2 mm Hg; P = .066). In contrast, no posttraining alterations were observed in N-terminal prohormone B-type natriuretic hormone, fibrinogen, and D-dimer values. During BFR exercise, all hemodynamic variables significantly increased after the first and second set, whereas blood pressure immediately lowered after the cuff was released in the third set. Last, significant interaction was only observed for repetitions × intensity (P < .001; partial η = 0.908) of diastolic blood pressure at higher exercise intensity (40% 1-repetition maximum). CONCLUSIONS: The BFR-RT was proven to be safe, with favorable hemodynamic and hemostatic responses in patients with CAD, and can be recommended as an additional exercise modality in cardiac rehabilitation. TRIAL REGISTRATION: ClinicalTrial.gov Identifier: NCT03087292.
RCT Entities:
BACKGROUND: Blood flow-restricted resistance training (BFR-RT) has been proven to be safe and efficacious in healthy older adults, but not in cardiovascular disease. OBJECTIVE: The aim of this study was to investigate the acute and training induced effects of BFR-RT on hemostatic and hemodynamic responses in patients with coronary artery disease (CAD). METHODS: Stable patients with CAD were randomized to 8 weeks of BFR-RT (30%-40% 1-repetition maximum unilateral knee extension) combined with aerobic training or aerobic training alone (control group). At baseline and after 4 and 8 weeks, blood samples were taken before and after BFR exercise, whereas hemodynamic parameters were monitored throughout the exercise. RESULTS: Twenty-four patients (12 per group; mean age, 60 ± 2 years; mostly male [75%]) completed the study. The BFR-RT significantly improved systolic blood pressure (-10 mm Hg; P = .020) and tended to lower diastolic blood pressure (-2 mm Hg; P = .066). In contrast, no posttraining alterations were observed in N-terminal prohormone B-type natriuretic hormone, fibrinogen, and D-dimer values. During BFR exercise, all hemodynamic variables significantly increased after the first and second set, whereas blood pressure immediately lowered after the cuff was released in the third set. Last, significant interaction was only observed for repetitions × intensity (P < .001; partial η = 0.908) of diastolic blood pressure at higher exercise intensity (40% 1-repetition maximum). CONCLUSIONS: The BFR-RT was proven to be safe, with favorable hemodynamic and hemostatic responses in patients with CAD, and can be recommended as an additional exercise modality in cardiac rehabilitation. TRIAL REGISTRATION: ClinicalTrial.gov Identifier: NCT03087292.
Authors: Dahan da Cunha Nascimento; Nicholas Rolnick; Ivo Vieira de Sousa Neto; Richard Severin; Fabiani Lage Rodrigues Beal Journal: Front Physiol Date: 2022-03-11 Impact factor: 4.566