Applied Mathematics of Ray Tracing and Perspective Projection in Fiducial-Based Registration of X-Ray Images.

Ray tracing (RT) and perspective projection (PP) using fiducial-based registration can be used to determine points of interest in biplanar X-ray imaging. We sought to investigate the implementation of these techniques as they pertain to X-ray imaging geometry. The mathematical solutions are presented and then implemented in a phantom and actual case with numerical tables and imaging. The X-ray imaging is treated like a Cartesian system in millimeters (mm) with a standard frame-based stereotactic system. In this space, the point source is the X-ray emitter (focal spot), the plane is the X-ray detector, and fiducials are in between the source and plane. In a phantom case, RT was able to predict locations of fiducials after moving the point source. Also, a scaled PP matrix could be used to determine imaging geometry, which could then be used in RT. Automated identification of spherical fiducials in 3D was possible using a center of mass computation with average Euclidean error relative to manual measurement of 0.23 mm. For PP, RT projection or a combinatorial approach could be used to facilitate matching 3D to 2D points. Despite being used herein for deep brain stimulation (DBS), utilization of this kind of imaging analysis has wide medical and non-medical applications.