Literature DB >> 32494040

Contributing ocular comorbidity to end-of-life visual acuity in medically treated glaucoma patients, ocular hypertension and glaucoma suspect patients.

Palwasha Mokhles1, Luuk van Gorcom2, Jan S A G Schouten2,3, Tos T J M Berendschot2, Henny J M Beckers2, Carroll A B Webers2.   

Abstract

AIM: To assess the visual acuity at the end of life in glaucoma suspect patients, ocular hypertension, and patients treated for glaucoma and to find factors contributing to a reduced visual acuity in this cohort of deceased patients.
METHODS: In a cohort of 3883 medically treated glaucoma patients, glaucoma suspect, or patients with ocular hypertension assembled in 2001-2004, 1639 were deceased. Patient data were collected from electronic and paper patient files. The files of 1378 patients were studied and the last measured visual acuity and ocular comorbidities influencing the visual acuity were extracted.
RESULTS: Our results show that only 37.2% of patients had no visual impairment in either eye, 30.5% was visually impaired or blind in both eyes and 4.1% was blind in both eyes, all based on VA. The most common contributing factors for severe visual impairment or blindness (prevalence ≥ 1%) were: glaucoma, retinal vein occlusion, dry and exudative age-related macular degeneration, past retinal detachment, amblyopia, diabetic retinopathy, anterior ischemic optic neuropathy, trauma, decompensated cornea, past keratitis, enucleation, corneal transplantation, and macular hole.
CONCLUSIONS: Despite the current advanced treatment modalities for glaucoma, 30.5% of patients had a VA < 0.5 in both eyes and 4.1% was blind in both eyes. However, this disability cannot be confidently attributed only to glaucoma. Besides glaucoma, most common contributing factors were among others retinal and macular diseases. Patient management in glaucoma should be based on more than lowering the intraocular pressure to prevent blindness at the end of life.

Entities:  

Year:  2020        PMID: 32494040      PMCID: PMC8027869          DOI: 10.1038/s41433-020-0991-0

Source DB:  PubMed          Journal:  Eye (Lond)        ISSN: 0950-222X            Impact factor:   3.775


  2 in total

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Journal:  Am Fam Physician       Date:  2016-08-01       Impact factor: 3.292

Review 2.  Glaucoma.

Authors:  Divakar Gupta; Philip P Chen
Journal:  Am Fam Physician       Date:  2016-04-15       Impact factor: 3.292

  2 in total
  2 in total

1.  Updates in Clinical and Translational Glaucoma Research.

Authors:  José Javier García-Medina; Maria Dolores Pinazo-Durán
Journal:  J Clin Med       Date:  2021-12-31       Impact factor: 4.241

2.  A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank.

Authors:  Guiying Dong; Jianfeng Feng; Fengzhu Sun; Jingqi Chen; Xing-Ming Zhao
Journal:  Genome Med       Date:  2021-07-05       Impact factor: 11.117

  2 in total

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