Sana Bint Aziz1, Gurkeerat Singh2. 1. Ex-Postgraduate Student, Department of Orthodontics and Dentofacial Orthopaedics, Sudha Rustagi College of Dental Sciences & Research, Faridabad, India. 2. Professor & Head, Department of Orthodontics and Dentofacial Orthopaedics, Sudha Rustagi College of Dental Sciences & Research, Faridabad, India.
Abstract
OBJECTIVE: The aim of this study was to assess & compare the changes in cytokine levels in GCF samples of patients wearing clear aligners. METHODS: GCF samples of 10 patients undergoing orthodontic treatment, for correction of lower anterior crowding with clear aligners, were collected on day 0, 1, 3, 7 and 21 using periopaper strips. The upper arch was taken as the control site. The samples collected were further analyzed using commercially available ELISA based kits. RESULTS: The mean levels of IL-1β at day 0, 1, 3, 7 and 21 were compared between experimental and control sites using unpaired t-test and it was found that the levels of IL-1β were significantly elevated on experimental site in comparison to control site. CONCLUSION: It was concluded from the study that elevation in levels of IL-1β as a biomarker of orthodontic tooth movement reaches its peak after 24 h of force application. The clear aligners, as an alternative to conventional fixed orthodontic treatment, were found to be efficient in correcting mild to moderate lower arch crowding.
OBJECTIVE: The aim of this study was to assess & compare the changes in cytokine levels in GCF samples of patients wearing clear aligners. METHODS: GCF samples of 10 patients undergoing orthodontic treatment, for correction of lower anterior crowding with clear aligners, were collected on day 0, 1, 3, 7 and 21 using periopaper strips. The upper arch was taken as the control site. The samples collected were further analyzed using commercially available ELISA based kits. RESULTS: The mean levels of IL-1β at day 0, 1, 3, 7 and 21 were compared between experimental and control sites using unpaired t-test and it was found that the levels of IL-1β were significantly elevated on experimental site in comparison to control site. CONCLUSION: It was concluded from the study that elevation in levels of IL-1β as a biomarker of orthodontic tooth movement reaches its peak after 24 h of force application. The clear aligners, as an alternative to conventional fixed orthodontic treatment, were found to be efficient in correcting mild to moderate lower arch crowding.
Authors: Laura R Iwasaki; Colin S Gibson; Larry D Crouch; David B Marx; Janardan P Pandey; Jeffrey C Nickel Journal: Am J Orthod Dentofacial Orthop Date: 2006-12 Impact factor: 2.650