| Literature DB >> 32488205 |
Bernhard Voelkl1, Naomi S Altman2, Anders Forsman3, Wolfgang Forstmeier4, Jessica Gurevitch5, Ivana Jaric1, Natasha A Karp6, Martien J Kas7, Holger Schielzeth8, Tom Van de Casteele9, Hanno Würbel10.
Abstract
Context-dependent biological variation presents a unique challenge to the reproducibility of results in experimental animal research, because organisms' responses to experimental treatments can vary with both genotype and environmental conditions. In March 2019, experts in animal biology, experimental design and statistics convened in Blonay, Switzerland, to discuss strategies addressing this challenge. In contrast to the current gold standard of rigorous standardization in experimental animal research, we recommend the use of systematic heterogenization of study samples and conditions by actively incorporating biological variation into study design through diversifying study samples and conditions. Here we provide the scientific rationale for this approach in the hope that researchers, regulators, funders and editors can embrace this paradigm shift. We also present a road map towards better practices in view of improving the reproducibility of animal research.Mesh：
Year: 2020 PMID： 32488205 DOI： 10.1038/s41583-020-0313-3
Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870