Jung Wook Yang1,2, Jeong-Hee Lee1,2,3, Jong Sil Lee1,2,3, Dong Chul Kim1,2,3, Dae Hyun Song1,3,4, Se Min Jang4, Hyo Jung An4, Hyun Min Koh4, Minhye Kim2, Ji Min Na2, Sang-Ho Jeong5, Young-Joon Lee5, Gyung Hyuck Ko6,2,3. 1. Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea. 2. Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea. 3. Gyungsang Institute of Health Science, Jinju, Republic of Korea. 4. Department of Pathology, Changwon Gyeongsang National University Hospital, Changwon, Republic of Korea. 5. Department of Surgery, Gyeongsang National University School of Medicine, Jinju, Republic of Korea. 6. Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea gyunghko@gnu.ac.kr.
Abstract
BACKGROUND/AIM: We aimed to evaluate the characteristics of gastric carcinoma with high excision repair cross complementing 1 (ERCC1) expression and the prognostic value of ERCC1 expression. MATERIALS AND METHODS: ERCC1 expression was evaluated by immunohistochemistry in 309 surgically resected gastric carcinoma specimens using a tissue microarray. Cancer-related survival was analysed using competing risk analysis. RESULTS: Compared to ERCC1-low gastric carcinomas, ERCC1-high gastric carcinomas showed less local invasion (p=0.0013), lower N stage (p=0.0302), earlier pTNM stage (p=0.0003), and less frequent recurrence (p=0002). Patients with ERCC1-high gastric carcinoma showed lower cumulative incidence function estimate of cancer-related death [3.37; 95% confidence intervaI (CI)=0.89-8.75] than did those with ERCC1-low gastric carcinoma (17.12; 95% CI=12.24-22.69; p-value by Gray's test=0.0012). Adjusted proportional sub-distribution hazard ratio for cancer-related death in the patients with ERCC1-high tumour was 0.272 (95% CI=0.084-0.878; p=0.0295). CONCLUSION: High ERCC1 expression may be an independent positive prognostic marker for gastric carcinoma. Copyright
BACKGROUND/AIM: We aimed to evaluate the characteristics of gastric carcinoma with high excision repair cross complementing 1 (ERCC1) expression and the prognostic value of ERCC1 expression. MATERIALS AND METHODS:ERCC1 expression was evaluated by immunohistochemistry in 309 surgically resected gastric carcinoma specimens using a tissue microarray. Cancer-related survival was analysed using competing risk analysis. RESULTS: Compared to ERCC1-low gastric carcinomas, ERCC1-high gastric carcinomas showed less local invasion (p=0.0013), lower N stage (p=0.0302), earlier pTNM stage (p=0.0003), and less frequent recurrence (p=0002). Patients with ERCC1-high gastric carcinoma showed lower cumulative incidence function estimate of cancer-related death [3.37; 95% confidence intervaI (CI)=0.89-8.75] than did those with ERCC1-low gastric carcinoma (17.12; 95% CI=12.24-22.69; p-value by Gray's test=0.0012). Adjusted proportional sub-distribution hazard ratio for cancer-related death in the patients with ERCC1-high tumour was 0.272 (95% CI=0.084-0.878; p=0.0295). CONCLUSION: High ERCC1 expression may be an independent positive prognostic marker for gastric carcinoma. Copyright