| Literature DB >> 32483760 |
M G Akimov1, P V Dudina2, E V Fomina-Ageeva2, N M Gretskaya2, A A Bosaya2, E V Rudakova3, G F Makhaeva3, G O Kagarlitsky4, S A Eremin4, V I Tsetlin2, V V Bezuglov2.
Abstract
The antioxidant activity and protective effect in the toxicity model of H2O2 were studied for arachidonic (AA-CHOL), docosahexaenoic (DHA-CHOL), linoleic (Ln-CHOL), and oleic (Ol-CHOL) fatty acids, as well as arachidonoyl dicholine (AA-diCHOL) and O-arachidonoyl bistetramethylaminoisopropanol (ABTAP). AA-CHOL, DHA-CHOL and Ln-CHOL provided a 20% increase in cell survival. AA-CHOL, AA-diCHOL, Ol-CHOL, and ABTAP had a radical-scavenging effect in the ABTS test, approximately equal to the activity of a standard radical scavenger Trolox.Entities:
Keywords: acylcholines; antioxidant activity; bisquaternized acylcholines; neuroprotection
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Year: 2020 PMID： 32483760 DOI： 10.1134/S1607672920020027
Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788