| Literature DB >> 32482837 |
Michaela R Anderson1, Imaani Easthausen2, Grace Gallagher3, Jayaram Udupa4, Yubing Tong4, Drew Torigian4, Joshua Matthew Diamond5, Mary Katherine Porteous5, Scott M Palmer6,7, Laurie D Snyder6, Luke Benvenuto3, Meghan Aversa3, Selim Arcasoy3, John R Greenland8,9, Steven R Hays9, Jasleen Kukreja10, Edward Cantu4, John Shinn Kim11, Dympna Gallagher3, Matthew R Baldwin3, R Graham Barr3, David J Lederer3,12, Jason D Christie4,5, Jonathan Paul Singer9.
Abstract
CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transplant candidates. Each ½-SD decrease in abdominal muscle attenuation (indicating greater lipid content) was associated with 14 m decrease in 6MWD (95% CI -20 to -8) and 20% increased risk of death or delisting (95% CI 10% to 40%). Each ½-standard deviation decrease in thigh muscle attenuation was associated with 15 m decrease in 6MWD (95% CI -21 to -10). CT imaging may improve candidate risk stratification. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.Entities:
Keywords: clinical epidemiology; imaging/CT MRI etc; lung transplantation
Mesh：
Year: 2020 PMID： 32482837 PMCID： PMC7888552 DOI： 10.1136/thoraxjnl-2019-214461
Source DB: PubMed Journal: Thorax ISSN： 0040-6376 Impact factor: 9.139