Literature DB >> 32482677

Fitness Cost and Compensatory Evolution in Levofloxacin-Resistant Mycobacterium aurum.

Rui Pi1, Qingyun Liu1, Howard E Takiff2,3,4, Qian Gao5.   

Abstract

We isolated spontaneous levofloxacin-resistant strains of Mycobacterium aurum to study the fitness cost and compensatory evolution of fluoroquinolone resistance in mycobacteria. Five of six mutant strains with substantial growth defects showed restored fitness after being serially passaged for 18 growth cycles, along with increased cellular ATP level. Whole-genome sequencing identified putative compensatory mutations in the glgC gene that restored the fitness of the resistant strains, presumably by altering the bacterial energy metabolism.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  compensatory mutation; fitness cost; levofloxacin; mycobacteria; resistance

Mesh：

Substances：

Year:  2020        PMID： 32482677      PMCID： PMC7526816          DOI： 10.1128/AAC.00224-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Population-based investigation of fluoroquinolones resistant tuberculosis in rural eastern China.

Authors:  Yi Hu; Barun Mathema; Weibing Wang; Barry Kreiswirth; Weili Jiang; Biao Xu
Journal:  Tuberculosis (Edinb)       Date:  2011-03-29       Impact factor: 3.131

2.  [Microdilution broth procedure].

Authors:  K Sugahara
Journal:  Rinsho Byori       Date:  1988-11

Review 3.  Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives.

Authors:  Sebastian M Gygli; Sonia Borrell; Andrej Trauner; Sebastien Gagneux
Journal:  FEMS Microbiol Rev       Date:  2017-05-01       Impact factor: 16.408

Review 4.  The Molecular Genetics of Fluoroquinolone Resistance in Mycobacterium tuberculosis.

Authors:  Claudine Mayer; Howard Takiff
Journal:  Microbiol Spectr       Date:  2014-08

5.  Quinolone resistance-associated amino acid substitutions affect enzymatic activity of Mycobacterium leprae DNA gyrase.

Authors:  Tomoyuki Yamaguchi; Kazumasa Yokoyama; Chie Nakajima; Yasuhiko Suzuki
Journal:  Biosci Biotechnol Biochem       Date:  2017-04-18       Impact factor: 2.043

6.  [The Spectrum of Mutations in Genes Associated with Resistance to Rifampicin, Isoniazid, and Fluoroquinolones in the Clinical Strains of M. tuberculosis Reflects the Transmissibility of Mutant Clones].

Authors:  A Ergeshov; S N Andreevskaya; E E Larionova; T G Smirnova; L N Chernousova
Journal:  Mol Biol (Mosk)       Date:  2017 Jul-Aug

7.  Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.

Authors:  Iñaki Comas; Sonia Borrell; Andreas Roetzer; Graham Rose; Bijaya Malla; Midori Kato-Maeda; James Galagan; Stefan Niemann; Sebastien Gagneux
Journal:  Nat Genet       Date:  2011-12-18       Impact factor: 38.330

8.  Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosis.

Authors:  Sònia Borrell; Youjin Teo; Federica Giardina; Elizabeth M Streicher; Marisa Klopper; Julia Feldmann; Borna Müller; Tommie C Victor; Sebastien Gagneux
Journal:  Evol Med Public Health       Date:  2013-03-08

Review 9.  The fitness costs of antibiotic resistance mutations.

Authors:  Anita H Melnyk; Alex Wong; Rees Kassen
Journal:  Evol Appl       Date:  2014-08-27       Impact factor: 5.183

10.  Predictive factors for unfavourable treatment in MDR-TB and XDR-TB patients in Rio de Janeiro State, Brazil, 2000-2016.

Authors:  Marcela Bhering; Raquel Duarte; Afrânio Kritski
Journal:  PLoS One       Date:  2019-11-20       Impact factor: 3.240
View more
  1 in total

1.  Large-Scale Analysis of Fitness Cost of tet(X4)-Positive Plasmids in Escherichia coli.

Authors:  Feifei Tang; Wenhui Cai; Lijie Jiang; Zhiqiang Wang; Yuan Liu
Journal:  Front Cell Infect Microbiol       Date:  2022-06-03       Impact factor: 6.073
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.