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Literature DB >> 32482456

Small Molecules Restore Telomeres in Patient Stem Cells.

Kirsten Ann Brenner¹, Jayakrishnan Nandakumar².

Abstract

Genetic defects in telomere maintenance result in stem cell exhaustion and a spectrum of telomere biology diseases. Systemic treatments beyond organ transplantation are lacking for these diseases. Nagpal and colleagues identified small molecules that restore telomere maintenance in patient-derived stem cells, offering a promising therapy for telomere biology diseases.

Entities: Chemical Disease Gene Species

Keywords: PAPD5; PARN; TERC; bone marrow failure; dyskeratosis congenita; telomerase

Mesh：

Substances：
RNA
Telomerase

Year: 2020 PMID： 32482456 PMCID： PMC7384241 DOI： 10.1016/j.tips.2020.05.003

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

15 in total

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Authors: J R Mitchell; E Wood; K Collins
Journal: Nature Date: 1999-12-02 Impact factor: 49.962

2. Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells.

Authors: Neha Nagpal; Jianing Wang; Jing Zeng; Emily Lo; Diane H Moon; Kevin Luk; Roman O Braun; Lauri M Burroughs; Sioban B Keel; Christopher Reilly; R Coleman Lindsley; Scot A Wolfe; Albert K Tai; Patrick Cahan; Daniel E Bauer; Yick W Fong; Suneet Agarwal
Journal: Cell Stem Cell Date: 2020-04-21 Impact factor: 24.633

3. Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease.

Authors: Caitlin M Roake; Lu Chen; Ananya L Chakravarthy; James E Ferrell; Grazia D Raffa; Steven E Artandi
Journal: Mol Cell Date: 2019-03-28 Impact factor: 17.970

4. X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions.

Authors: N S Heiss; S W Knight; T J Vulliamy; S M Klauck; S Wiemann; P J Mason; A Poustka; I Dokal
Journal: Nat Genet Date: 1998-05 Impact factor: 38.330

5. Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.

Authors: Hemanth Tummala; Amanda Walne; Laura Collopy; Shirleny Cardoso; Josu de la Fuente; Sarah Lawson; James Powell; Nicola Cooper; Alison Foster; Shehla Mohammed; Vincent Plagnol; Thomas Vulliamy; Inderjeet Dokal
Journal: J Clin Invest Date: 2015-04-20 Impact factor: 14.808

6. Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita.

Authors: Wilson Chun Fok; Siddharth Shukla; Alexandre Teixeira Vessoni; Kirsten Ann Brenner; Roy Parker; Christopher M Sturgeon; Luis Francisco Zirnberger Batista
Journal: Blood Date: 2019-02-06 Impact factor: 22.113

7. Specific association of human telomerase activity with immortal cells and cancer.

Authors: N W Kim; M A Piatyszek; K R Prowse; C B Harley; M D West; P L Ho; G M Coviello; W E Wright; S L Weinrich; J W Shay
Journal: Science Date: 1994-12-23 Impact factor: 47.728

8. PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization.

Authors: Henrik Mueller; Anaïs Lopez; Philipp Tropberger; Steffen Wildum; Josephine Schmaler; Lykke Pedersen; Xingchun Han; Yongguang Wang; Søren Ottosen; Song Yang; John A T Young; Hassan Javanbakht
Journal: Hepatology Date: 2019-03-01 Impact factor: 17.425

9. Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.

Authors: Bridget D Stuart; Jungmin Choi; Samir Zaidi; Chao Xing; Brody Holohan; Rui Chen; Mihwa Choi; Pooja Dharwadkar; Fernando Torres; Carlos E Girod; Jonathan Weissler; John Fitzgerald; Corey Kershaw; Julia Klesney-Tait; Yolanda Mageto; Jerry W Shay; Weizhen Ji; Kaya Bilguvar; Shrikant Mane; Richard P Lifton; Christine Kim Garcia
Journal: Nat Genet Date: 2015-04-13 Impact factor: 41.307