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Literature DB >> 32480246

Role of CD38/cADPR signaling in obstructive pulmonary diseases.

Alonso Gp Guedes¹, Mythili Dileepan², Joseph A Jude³, Deepak A Deshpande⁴, Timothy F Walseth⁵, Mathur S Kannan².

Abstract

The worldwide socioeconomical burden associated with chronic respiratory diseases is substantial. Enzymes involved in the metabolism of nicotinamide adenine dinucleotide (NAD) are increasingly being implicated in chronic airway diseases. One such enzyme, CD38, utilizes NAD to produce several metabolites, including cyclic ADP ribose (cADPR), which is involved in calcium signaling in airway smooth muscle (ASM). Upregulation of CD38 in ASM caused by exposure to cytokines or allergens leads to enhanced calcium mobilization by agonists and the development of airway hyperresponsiveness (AHR) to contractile agonists. Glucocorticoids and microRNAs can suppress CD38 expression in ASM, whereas cADPR antagonists such as 8Br-cADPR can directly antagonize intracellular calcium mobilization. Bronchodilators act via CD38-independent mechanisms. CD38-dependent mechanisms could be developed for chronic airway diseases therapy.

Entities: Chemical Disease Gene Species

Year: 2020 PMID： 32480246 PMCID： PMC7529733 DOI： 10.1016/j.coph.2020.04.007

Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547

52 in total

1. Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010.

Authors: Lara J Akinbami; Jeanne E Moorman; Cathy Bailey; Hatice S Zahran; Michele King; Carol A Johnson; Xiang Liu
Journal: NCHS Data Brief Date: 2012-05

2. The Economic Burden of Asthma in the United States, 2008-2013.

Authors: Tursynbek Nurmagambetov; Robin Kuwahara; Paul Garbe
Journal: Ann Am Thorac Soc Date: 2018-03

3. Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases.

Authors: Joseph A Jude; Krishnaswamy G Tirumurugaan; Bit Na Kang; Reynold A Panettieri; Timothy F Walseth; Mathur S Kannan
Journal: Am J Respir Cell Mol Biol Date: 2012-05-03 Impact factor: 6.914

4. Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells.

Authors: Joseph A Jude; Julian Solway; Reynold A Panettieri; Timothy F Walseth; Mathur S Kannan
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2010-08-06 Impact factor: 5.464

5. CD38 gene-modified dendritic cells inhibit murine asthma development by increasing IL-12 production and promoting Th1 cell differentiation.

Authors: Jiaoli Wang; Weiguo Zhu; Yinghu Chen; Zhendong Lin; Shenglin Ma
Journal: Mol Med Rep Date: 2016-09-21 Impact factor: 2.952

6. Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses.

Authors: D A Cockayne; T Muchamuel; J C Grimaldi; H Muller-Steffner; T D Randall; F E Lund; R Murray; F Schuber; M C Howard
Journal: Blood Date: 1998-08-15 Impact factor: 22.113

7. PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.

Authors: Mohamed A Ghonim; Kusma Pyakurel; Salome V Ibba; Amir A Al-Khami; Jeffrey Wang; Paulo Rodriguez; Hamada F Rady; Ali H El-Bahrawy; Matthew R Lammi; Moselhy S Mansy; Kamel Al-Ghareeb; Alistair Ramsay; Augusto Ochoa; Amarjit S Naura; A Hamid Boulares
Journal: J Transl Med Date: 2015-07-14 Impact factor: 5.531

8. Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients.

Authors: Nailya Kubysheva; Larisa Postnikova; Svetlana Soodaeva; Viкtor Novikov; Tatyana Eliseeva; Ildar Batyrshin; Timur Li; Igor Klimanov; Alexander Chuchalin
Journal: Dis Markers Date: 2017-08-07 Impact factor: 3.434

Role of CD38/cADPR signaling in obstructive pulmonary diseases.

1. Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010.

2. The Economic Burden of Asthma in the United States, 2008-2013.

3. Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases.

4. Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells.

5. CD38 gene-modified dendritic cells inhibit murine asthma development by increasing IL-12 production and promoting Th1 cell differentiation.

6. Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses.

7. PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.

8. Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients.

Review 9. NAD⁺ metabolism as a target for metabolic health: have we found the silver bullet?

10. Analysis of the distribution of human CD38 and of its ligand CD31 in normal tissues.

1. Differences in Extracellular NAD⁺ and NMN Metabolism on the Surface of Vascular Endothelial Cells.

2. Downregulation of miR-140-3p Contributes to Upregulation of CD38 Protein in Bronchial Smooth Muscle Cells.

3. Identification of a dihydropyridine scaffold that blocks ryanodine receptors.

Review 9. NAD+ metabolism as a target for metabolic health: have we found the silver bullet?

Review 9. NAD⁺ metabolism as a target for metabolic health: have we found the silver bullet?