Ana Thalita Gonçalves Soares1, Aline de Castro Silva1, Alexey A Tinkov2, Haroon Khan3, Abel Santamaría4, Margarita G Skalnaya5, Anatoly V Skalny6, Aristidis Tsatsakis7, Aaron B Bowman8, Michael Aschner9, Daiana Silva Ávila10. 1. Laboratory of Biochemistry and Toxicology in Caenorhabditis elegans, Graduation Program in Biochemistry, Federal University of Pampa Campus Uruguaiana, RS, Brazil. 2. Yaroslavl State University, Yaroslavl, Russia; IM Sechenov First Moscow State Medical University, Moscow, Russia; Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 460000 Orenburg, Russia. 3. Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan. 4. Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, SSA, Mexico City, Mexico. 5. IM Sechenov First Moscow State Medical University, Moscow, Russia. 6. IM Sechenov First Moscow State Medical University, Moscow, Russia; Federal Scientific Center of Biological Systems and Agrotechnologies of the Russian Academy of Sciences, 460000 Orenburg, Russia. 7. Laboratory of Toxicology, Medical School, School of Medicine, University of Crete, Heraklion 71003, Greece. 8. School of Health Sciences, Purdue University, West Lafayette 47906, IN, USA. 9. IM Sechenov First Moscow State Medical University, Moscow, Russia; Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. 10. Laboratory of Biochemistry and Toxicology in Caenorhabditis elegans, Graduation Program in Biochemistry, Federal University of Pampa Campus Uruguaiana, RS, Brazil. Electronic address: daianaavila@unipampa.edu.br.
Abstract
BACKGROUND: Manganese (Mn) is a metal ubiquitously present in nature and essential for many living organisms. As a trace element, it is required in small amounts for the proper functioning of several important enzymes, and reports of Mn deficiency are indeed rare. METHODS: This mini-review will cover aspects of Mn toxicokinetics and its impact on brain neurotransmission, as well as its Janus-faced effects on humans and other animal's health. RESULTS: The estimated safe upper limit of intracellular Mn for physiological function is in anarrow range of 20-53 μM.Therefore, intake of higher levels of Mn and the outcomes, especially to the nervous system, have been well documented. CONCLUSION: The metal affects mostly the brain by accumulating in specific areas, altering cognitive functions and locomotion, thus severely impacting the health of the exposed organisms.
BACKGROUND:Manganese (Mn) is a metal ubiquitously present in nature and essential for many living organisms. As a trace element, it is required in small amounts for the proper functioning of several important enzymes, and reports of Mn deficiency are indeed rare. METHODS: This mini-review will cover aspects of Mn toxicokinetics and its impact on brain neurotransmission, as well as its Janus-faced effects on humans and other animal's health. RESULTS: The estimated safe upper limit of intracellular Mn for physiological function is in anarrow range of 20-53 μM.Therefore, intake of higher levels of Mn and the outcomes, especially to the nervous system, have been well documented. CONCLUSION: The metal affects mostly the brain by accumulating in specific areas, altering cognitive functions and locomotion, thus severely impacting the health of the exposed organisms.
Authors: Karin Tuschl; Richard J White; Chintan Trivedi; Leonardo E Valdivia; Stephanie Niklaus; Isaac H Bianco; Chris Dadswell; Ramón González-Méndez; Ian M Sealy; Stephan C F Neuhauss; Corinne Houart; Jason Rihel; Stephen W Wilson; Elisabeth M Busch-Nentwich Journal: Dis Model Mech Date: 2022-06-15 Impact factor: 5.732
Authors: Alexey A Tinkov; Monica M B Paoliello; Aksana N Mazilina; Anatoly V Skalny; Airton C Martins; Olga N Voskresenskaya; Jan Aaseth; Abel Santamaria; Svetlana V Notova; Aristides Tsatsakis; Eunsook Lee; Aaron B Bowman; Michael Aschner Journal: Int J Mol Sci Date: 2021-04-28 Impact factor: 5.923
Authors: Félix Javier Jiménez-Jiménez; Pedro Ayuso; Hortensia Alonso-Navarro; Marisol Calleja; Mónica Díez-Fairén; Ignacio Álvarez; Pau Pastor; José Francisco Plaza-Nieto; Santiago Navarro-Muñoz; Laura Turpín-Fenoll; Jorge Millán-Pascual; Marta Recio-Bermejo; Rafael García-Ruiz; Esteban García-Albea; José A G Agúndez; Elena García-Martín Journal: Antioxidants (Basel) Date: 2022-01-29