Literature DB >> 32477648

Text Snippets to Corroborate Medical Relations: An Unsupervised Approach using a Knowledge Graph and Embeddings.

Maulik R Kamdar1, Craig E Stanley1, Michael Carroll1, Linda Wogulis1, William Dowling1, Helena F Deus1, Mevan Samarasinghe1.   

Abstract

Knowledge graphs have been shown to significantly improve search results. Usually populated by subject matter experts, relations therein need to keep up to date with medical literature in order for search to remain relevant. Dynamically identifying text snippets in literature that confirm or deny knowledge graph triples is increasingly becoming the differentiator between trusted and untrusted medical decision support systems. This work describes our approach to mapping triples to medical text. A medical knowledge graph is used as a source of triples that are used to find matching sentences in reference text. Our unsupervised approach uses phrase embeddings and cosine similarity measures, and boosts candidate text snippets when certain key concepts exist. Using this approach, we can accurately map semantic relations within the medical knowledge graph to text snippets with a precision of 61.4% and recall of 86.3%. This method will be used to develop a novel application in the future to retrieve medical relations and corroborating snippets from medical text given a user query. ©2020 AMIA - All rights reserved.

Year:  2020        PMID: 32477648      PMCID: PMC7233036     

Source DB:  PubMed          Journal:  AMIA Jt Summits Transl Sci Proc


  5 in total

1.  Proteomic Network Analysis of Bronchoalveolar Lavage Fluid in Ex-Smokers to Discover Implicated Protein Targets and Novel Drug Treatments for Chronic Obstructive Pulmonary Disease.

Authors:  Manoj J Mammen; Chengjian Tu; Matthew C Morris; Spencer Richman; William Mangione; Zackary Falls; Jun Qu; Gordon Broderick; Sanjay Sethi; Ram Samudrala
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-01

2.  An empirical meta-analysis of the life sciences linked open data on the web.

Authors:  Maulik R Kamdar; Mark A Musen
Journal:  Sci Data       Date:  2021-01-21       Impact factor: 6.444

3.  Mapping the network biology of metabolic response to stress in posttraumatic stress disorder and obesity.

Authors:  Thomas P Chacko; J Tory Toole; Spencer Richman; Garry L Spink; Matthew J Reinhard; Ryan C Brewster; Michelle E Costanzo; Gordon Broderick
Journal:  Front Psychol       Date:  2022-07-26

4.  Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine storm.

Authors:  Spencer Richman; Cole Lyman; Matthew Morris; Gordon Broderick; Anastasia Nesterova; Anton Yuryev; Hongbao Cao; Chris Cheadle; Gary Skuse
Journal:  NPJ Syst Biol Appl       Date:  2022-10-10

5.  Development of a semi-structured, multifaceted, computer-aided questionnaire for outbreak investigation: e-Outbreak Platform.

Authors:  Wei J Chen; Shih-Yi Yang; Jung-Chih Chang; Wei-Che Cheng; Tzu-Pin Lu; Yu-Neng Wang; Ming-Hao Juan; Ruey-Tzer Hsu; Song-Ren Huang; Jia-Jang Tu; Pang-Chieh Wang; Vincent W-S Feng; Pei-Zen Chang
Journal:  Biomed J       Date:  2020-06-20       Impact factor: 4.910

  5 in total

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