Literature DB >> 32476900

A case report of steroid resistant cardiac sarcoidosis successfully managed with methotrexate.

Olga Grabowska1, Magdalena M Martusewicz-Boros2, Dorota Piotrowska-Kownacka3, Elżbieta Wiatr2.   

Abstract

Up to one fourth of sarcoidosis patients may have cardiac involvement, what is potentially a life-threatening condition and requires aggressive treatment. Corticosteroids are generally effective in cardiac sarcoidosis, however may have significant short and long term adverse effects. We present a case of a 42-year-old male, who was diagnosed with pulmonary and cardiac sarcoidosis. He was treated initially with corticosteroids and satisfactory improvement was achieved in the lungs but not in the heart. Methotrexate was added as a second line therapy, being beneficial for the heart as well as steroid sparing agent. Cardiac improvement was documented during serial CMR imaging. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 178-181). Copyright:
© 2018.

Entities:  

Keywords:  cardiac sarcoidosis; corticosteroids; methotrexate; sarcoidosis

Year:  2018        PMID: 32476900      PMCID: PMC7170091          DOI: 10.36141/svdld.v35i2.6554

Source DB:  PubMed          Journal:  Sarcoidosis Vasc Diffuse Lung Dis        ISSN: 1124-0490            Impact factor:   0.670


  12 in total

1.  Effect of Corticosteroid Therapy on Long-Term Clinical Outcome and Left Ventricular Function in Patients With Cardiac Sarcoidosis.

Authors:  Toshiyuki Nagai; Nobutaka Nagano; Yasuo Sugano; Yasuhide Asaumi; Takeshi Aiba; Hideaki Kanzaki; Kengo Kusano; Teruo Noguchi; Satoshi Yasuda; Hisao Ogawa; Toshihisa Anzai
Journal:  Circ J       Date:  2015-04-16       Impact factor: 2.993

2.  The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool.

Authors:  Marc A Judson; Ulrich Costabel; Marjolein Drent; Athol Wells; Lisa Maier; Laura Koth; Hidenobu Shigemitsu; Dan A Culver; Jeffrey Gelfand; Dominique Valeyre; Nadera Sweiss; Elliott Crouser; Adam S Morgenthau; Elyse E Lower; Arata Azuma; Mami Ishihara; Shin-Ichiro Morimoto; Tetsuo Tetsuo Yamaguchi; Noriharu Shijubo; Jan C Grutters; Misha Rosenbach; Hui-Ping Li; Paola Rottoli; Yoshikazu Inoue; Antje Prasse; Robert P Baughman; The Wasog Sarcoidosis Organ Assessment Instrument Investigators
Journal:  Sarcoidosis Vasc Diffuse Lung Dis       Date:  2014-04-18       Impact factor: 0.670

3.  HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis.

Authors:  David H Birnie; William H Sauer; Frank Bogun; Joshua M Cooper; Daniel A Culver; Claire S Duvernoy; Marc A Judson; Jordana Kron; Davendra Mehta; Jens Cosedis Nielsen; Amit R Patel; Tohru Ohe; Pekka Raatikainen; Kyoko Soejima
Journal:  Heart Rhythm       Date:  2014-05-09       Impact factor: 6.343

4.  Clinical characteristics of patients in a case control study of sarcoidosis.

Authors:  R P Baughman; A S Teirstein; M A Judson; M D Rossman; H Yeager; E A Bresnitz; L DePalo; G Hunninghake; M C Iannuzzi; C J Johns; G McLennan; D R Moller; L S Newman; D L Rabin; C Rose; B Rybicki; S E Weinberger; M L Terrin; G L Knatterud; R Cherniak
Journal:  Am J Respir Crit Care Med       Date:  2001-11-15       Impact factor: 21.405

Review 5.  Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999.

Authors: 
Journal:  Am J Respir Crit Care Med       Date:  1999-08       Impact factor: 21.405

6.  Cardiac sarcoidosis: a retrospective study of 41 cases.

Authors:  Catherine Chapelon-Abric; Dominique de Zuttere; Pierre Duhaut; Pierre Veyssier; Bertrand Wechsler; Du Le Thi Huong; Christian de Gennes; Thomas Papo; Olivier Blétry; Pierre Godeau; Jean-Charles Piette
Journal:  Medicine (Baltimore)       Date:  2004-11       Impact factor: 1.889

7.  Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone.

Authors:  Y Yazaki; M Isobe; M Hiroe; S Morimoto; S Hiramitsu; T Nakano; T Izumi; M Sekiguchi
Journal:  Am J Cardiol       Date:  2001-11-01       Impact factor: 2.778

Review 8.  Cardiac sarcoid: a clinician's review on how to approach the patient with cardiac sarcoid.

Authors:  Nicholas Mantini; Byron Williams; Jim Stewart; Leon Rubinsztain; Andro Kacharava
Journal:  Clin Cardiol       Date:  2012-04-12       Impact factor: 2.882

9.  Treatment with methotrexate and low-dose corticosteroids in sarcoidosis patients with cardiac lesions.

Authors:  Sonoko Nagai; Takafumi Yokomatsu; Kiminobu Tanizawa; Kohei Ikezoe; Tomohiro Handa; Yutaka Ito; Shunpei Ogino; Takateru Izumi
Journal:  Intern Med       Date:  2014       Impact factor: 1.271

10.  Cardiac sarcoid: a clinicopathologic study of 84 unselected patients with systemic sarcoidosis.

Authors:  K J Silverman; G M Hutchins; B H Bulkley
Journal:  Circulation       Date:  1978-12       Impact factor: 29.690

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  1 in total

1.  Effectiveness of methotrexate as a second-line treatment for cardiac sarcoidosis assessed via 18F-FDG PET: a case report.

Authors:  Taishi Dotare; Daichi Maeda; Yuya Matsue; Tohru Minamino
Journal:  Eur Heart J Case Rep       Date:  2022-05-31
  1 in total

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