Literature DB >> 32476873

New advances in the development of sarcoidosis models: a synopsis of a symposium sponsored by the Foundation for Sarcoidosis Research.

Jacobo Sellares1,2,3, Irina Strambu4, Elliot D Crouser5, Marina A Freudenberg6, Mridu Gulati7, Simon Hart8, Erika Herzog7, Martin Kolb9, Thomas Weichhart10, Wonder P Drake11, Ginger Spitzer12, Noopur Singh12, Daniel A Culver13.   

Abstract

Sarcoidosis is a complex disease with variable phenotypes that will require a multisystem approach to understand pathophysiology. One of the most challenging problems in sarcoidosis research is the absence of valid and widely accepted experimental models that accurately simulate human disease. The Foundation of Sarcoidosis Research (FSR) has funded five projects for the development of novel experimental models for sarcoidosis, presented and discussed in a workshop organized during the European Respiratory Society Congress held in Milan from September 9th to 13th. The experimental, in vivo or in sillico models presented may be quite helpful for investigating specific pathogenic and therapeutic questions, addressing especially severe forms of sarcoidosis. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 2-4). Copyright:
© 2018.

Entities:  

Keywords:  models; pathogenesis; sarcoidosis

Year:  2018        PMID: 32476873      PMCID: PMC7170054          DOI: 10.36141/svdld.v35i1.7032

Source DB:  PubMed          Journal:  Sarcoidosis Vasc Diffuse Lung Dis        ISSN: 1124-0490            Impact factor:   0.670


  8 in total

1.  Update on models of pulmonary fibrosis therapy for preclinical drug research.

Authors:  Sabina Antonela Antoniu; Martin Rj Kolb
Journal:  Expert Opin Drug Discov       Date:  2009-09       Impact factor: 6.098

2.  Fibroblast engraftment in the decellularized mouse lung occurs via a β1-integrin-dependent, FAK-dependent pathway that is mediated by ERK and opposed by AKT.

Authors:  Huanxing Sun; Elizabeth Calle; Xiaosong Chen; Aditi Mathur; Yangyang Zhu; Julio Mendez; Liping Zhao; Laura Niklason; Xueyan Peng; Hong Peng; Erica L Herzog
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2013-12-13       Impact factor: 5.464

3.  A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection.

Authors:  Elliott D Crouser; Peter White; Evelyn Guirado Caceres; Mark W Julian; Audrey C Papp; Landon W Locke; Wolfgang Sadee; Larry S Schlesinger
Journal:  Am J Respir Cell Mol Biol       Date:  2017-10       Impact factor: 6.914

Review 4.  High-Risk Sarcoidosis. Current Concepts and Research Imperatives.

Authors:  William H Sauer; Barney J Stern; Robert P Baughman; Daniel A Culver; Walter Royal
Journal:  Ann Am Thorac Soc       Date:  2017-12

Review 5.  Experimental models of sarcoidosis.

Authors:  Florence Jeny; Yves Pacheco; Valerie Besnard; Dominique Valeyre; Jean-François Bernaudin
Journal:  Curr Opin Pulm Med       Date:  2016-09       Impact factor: 3.155

6.  An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis.

Authors:  R Gisli Jenkins; Bethany B Moore; Rachel C Chambers; Oliver Eickelberg; Melanie Königshoff; Martin Kolb; Geoffrey J Laurent; Carmel B Nanthakumar; Mitchell A Olman; Annie Pardo; Moises Selman; Dean Sheppard; Patricia J Sime; Andrew M Tager; Amanda L Tatler; Victor J Thannickal; Eric S White
Journal:  Am J Respir Cell Mol Biol       Date:  2017-05       Impact factor: 7.748

7.  A Petri net model of granulomatous inflammation: implications for IL-10 mediated control of Leishmania donovani infection.

Authors:  Luca Albergante; Jon Timmis; Lynette Beattie; Paul M Kaye
Journal:  PLoS Comput Biol       Date:  2013-11-21       Impact factor: 4.475

8.  Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression.

Authors:  Monika Linke; Ha Thi Thanh Pham; Karl Katholnig; Thomas Schnöller; Anne Miller; Florian Demel; Birgit Schütz; Margit Rosner; Boris Kovacic; Nyamdelger Sukhbaatar; Birgit Niederreiter; Stephan Blüml; Peter Kuess; Veronika Sexl; Mathias Müller; Mario Mikula; Wolfram Weckwerth; Arvand Haschemi; Martin Susani; Markus Hengstschläger; Michael J Gambello; Thomas Weichhart
Journal:  Nat Immunol       Date:  2017-01-16       Impact factor: 25.606

  8 in total
  2 in total

1.  Matrix Metalloproteinase-12 Is Required for Granuloma Progression.

Authors:  Arjun Mohan; Nicole Neequaye; Anagha Malur; Eman Soliman; Matthew McPeek; Nancy Leffler; David Ogburn; Debra A Tokarz; Warren Knudson; Sina A Gharib; Lynn M Schnapp; Barbara P Barna; Mary Jane Thomassen
Journal:  Front Immunol       Date:  2020-09-18       Impact factor: 7.561

Review 2.  Sarcoidosis: Progression to the chronic stage and pathogenic based treatment (narrative review).

Authors:  Anna Malkova; Yulia Zinchenko; Anna Starshinova; Dmitriy Kudlay; Igor Kudryavtsev; Anzhela Glushkova; Piotr Yablonskiy; Yehuda Shoenfeld
Journal:  Front Med (Lausanne)       Date:  2022-09-06
  2 in total

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