Manisha Kumar 1 , Aayushi Hasija 1 , Nikita Garg 1 , Ramya Mishra 1 , S C Roy Chaudhary 2 Show Affiliations »
Abstract
OBJECTIVES: To find out the relative prevalence of fetal neural tube defect (NTD) and its outcome in terms of survival at birth and beyond 2 years of age. METHODS: A 10-year prospective (2008-2018) observational study was performed, which included all prenatally detected fetal NTD. Two-year follow-up was done in cases of pregnancies resulting in live birth, in terms of their survival, physical morbidity and developmental delay. RESULTS: NTD was seen in 401/648 (62%) cases among the central nervous system malformations. More than half of the cases (54.1%) presented after 20 weeks of gestation, and 42.8% of the mothers were primiparous. Spina bifida was seen in 206 cases, anencephaly in 144, encephalocele in 43, whereas iniencephaly was seen in only eight cases. Associated anomalies were present in 51.2%. Only 19.0% cases were live-born, and merely 11% were alive beyond 2 years of age. Among types of spina bifida, lumbosacral meningomyocele was the most common (41.6%), whereas thoracic was the rarest (8.7%). After 2 years, physical disability was observed in more than half of the cases who survived. CONCLUSIONS: NTD is one of the commonest malformations with high mortality, and the physical and mental sub-normality is high among those who survive. © Federation of Obstetric & Gynecological Societies of India 2020.
OBJECTIVES: To find out the relative prevalence of fetal neural tube defect (NTD) and its outcome in terms of survival at birth and beyond 2 years of age. METHODS: A 10-year prospective (2008-2018) observational study was performed, which included all prenatally detected fetal NTD. Two-year follow-up was done in cases of pregnancies resulting in live birth, in terms of their survival, physical morbidity and developmental delay. RESULTS: NTD was seen in 401/648 (62%) cases among the central nervous system malformations. More than half of the cases (54.1%) presented after 20 weeks of gestation, and 42.8% of the mothers were primiparous. Spina bifida was seen in 206 cases, anencephaly in 144, encephalocele in 43, whereas iniencephaly was seen in only eight cases. Associated anomalies were present in 51.2%. Only 19.0% cases were live-born, and merely 11% were alive beyond 2 years of age. Among types of spina bifida, lumbosacral meningomyocele was the most common (41.6%), whereas thoracic was the rarest (8.7%). After 2 years, physical disability was observed in more than half of the cases who survived. CONCLUSIONS: NTD is one of the commonest malformations with high mortality, and the physical and mental sub-normality is high among those who survive. © Federation of Obstetric & Gynecological Societies of India 2020.
Entities: Chemical
Keywords:
Anencephaly; Central nervous system anomaly; Encephalocele; Fetal hydrocephalus; India; Spina bifida; Survival after birth
Year: 2020
PMID： 32476765 PMCID： PMC7239972 DOI： 10.1007/s13224-020-01311-x
Source DB: PubMed Journal: J Obstet Gynaecol India ISSN： 0975-6434